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- W1999705428 abstract "A diselenide, 2,2′-diseleno-bis-β-cyclodextrin (2-SeCD), was synthesized to imitate the antioxidant enzyme glutathione peroxidase (GPX). The GPX mimic accepts a variety of hydroperoxides as substrates. The GPX activities, reduction of H2O2, tert-butyl hydroperoxide and cumenyl hydroperoxide by glutathione, are 7.4, 4.5 and 10.2 U/μmol, respectively. In contrast to ebselen (PZ51), the diselenide displays high GPX-like activity. The reduction of hydroperoxide by glutathione in the presence of a radical trap shows that the mimic catalyzes the reaction via a non-radical mechanism. A ping-pong mechanism was observed in the steady-state kinetic studies of the 2-SeCD-catalyzed reaction." @default.
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- W1999705428 date "2000-09-01" @default.
- W1999705428 modified "2023-10-11" @default.
- W1999705428 title "A bis-cyclodextrin diselenide with glutathione peroxidase-like activity" @default.
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- W1999705428 doi "https://doi.org/10.1016/s0167-4838(00)00130-8" @default.
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