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- W1999712302 abstract "Vascular endothelial cell (EC) adhesion and migration are essential processes in re-endothelialization of implanted biomaterials, which are affected by surface properties of implanted materials such as surface wettability. Our previous study demonstrated that, as model substrates, EC adhesion/migration showed an opposite behavior on the hydrophobic and hydrophilic surfaces of plasma SiOx:H nanocoatings. Extending our previous works, the expression and distribution of crucial proteins in integrins-FAK-Rho GTPases signaling pathways were examined, respectively. The results showed that a hydrophilic surface could enhance the expression of focal adhesion protein associated with cell adhesion; however, the hydrophobic surface could improve the expression of Rho GTPases associated with cell migration and phosphorylation level of FAK, revealing the potential reason of surface wettability mediating different cells' adhesion/migration behaviors. These findings reveal the relationship and molecular mechanism of endothelial cell adhesion/migration, which was expected to guide the surface modification of implants for accelerating endothelialization." @default.
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- W1999712302 date "2013-05-15" @default.
- W1999712302 modified "2023-09-23" @default.
- W1999712302 title "Integrins-FAK-Rho GTPases Pathway in Endothelial Cells Sense and Response to Surface Wettability of Plasma Nanocoatings" @default.
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- W1999712302 doi "https://doi.org/10.1021/am400973a" @default.
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