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- W1999714034 abstract "Introduction: Objective: We aimed to determine if Idiopathic Gastroparesis could occur in children and Erythromycin as prokinatic improve gastric emptying and reduces symptoms in those patients. Methods: Study Subjects: Patients with symptomatic gastroparesis were enrollment in this open-label pilot study. Idiopathic gastroparesis was diagnosed and documented by prior gastric emptying scintigraphy and upper endoscopy with symptoms of nausea, vomiting and /or early satiety. Patients were excluded if they 1) had a mechanical cause for delayed gastric emptying e.g. peptic ulcer.2) had diabetes mellitus. 3) had a known coagulopathy. 4)H- pylori positive(by histopathological examination of antral biopsies).5)Medication 15 days prior to enrollment in this study. Study Protocol: Total symptom scores were obtained from the sum of eight upper G.I.T symptoms graded on scale from 0(none) to 4 (extreme). Patients then underwent combined solid-liquid gastric emptying scintigraphy. If the gastric emptying was delayed, patients then underwent upper endoscopy. If no exclusion criteria, so diagnoses of Idiopathic gastroparesis was made. Patients were assessed for symptoms in follow up at 2 and 4 WK after treatment with Erythromycin Results: Ten children were entered into the study. The mean percentage of solid gastric retention at 4 h improved from 28=3 (normal <10%) before Erythromycin treatment to 15+1 (P =0.037) 4 WK after treatment the symptom score decreased from 16+1.4 at baseline to 10+1.6(P=0.015) at 4WK, 38+6% decrease. Improvement in symptoms tended to correlate with improved gastric emptying of solids(r=0.574, P=0.078) Conclusion: This initial pilot study suggests that Idiopathic Gastroparesis could occur in children as adult and its treatment with Erythromycin improves both gastric emptying and symptoms." @default.
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- W1999714034 date "2004-06-01" @default.
- W1999714034 modified "2023-09-25" @default.
- W1999714034 title "P0983 IDIOPATHIC GASTROPARESIS IN CHILDREN & ITS TREATMENT WITH ERYTHROMYCIN" @default.
- W1999714034 cites W1549402665 @default.
- W1999714034 doi "https://doi.org/10.1097/00005176-200406001-01107" @default.
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