FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999715467> ?p ?o ?g. }

• W1999715467 endingPage "449" @default.
• W1999715467 startingPage "443" @default.
• W1999715467 abstract "Eighteen children with perennial asthma and allergy to house-dust mite (HDM) underwent a bronchial challenge with HDM. Before and 24 h after the test, a venous blood sample was taken to determine levels of eosinophils, eosinophil cationic protein (ECP), soluble interleukin-2 receptor (IL-2R), and interleukin-6 (IL-6). A histamine challenge was performed before and 24 h after the HDM challenge. All subjects showed an immediate asthmatic reaction (IAR). A definite late asthmatic reaction (LAR) was observed in 15 children, a probable LAR in two, and no LAR in one. Because of persistent bronchial obstruction (FEV1>70%), eight children were unable to perform a histamine challenge 24 h after the allergen challenge. These were the children with the lowest prechallenge provocation dose (PD20) of histamine. In the other 10 children, the mean PD20 histamine decreased after the HDM challenge (mean PD20 before was 0.56 mg/ml; after challenge it was 0.14 mg/ml; P= 0.007). After the HDM challenge, an increase was detected in the mean values of blood eosinophils (mean before was 446/mm3; mean after was 733/mm3; P= 0.002), ECP (mean before was 26.3 μg/1; mean after was 34.3 μg/1; P<0.040), and IL-2R (mean before was 116.35 U/ml; mean after was 128.52 U/ml; P<0.040). On the other hand, IL-6 remained unchanged after the HDM challenge (mean before was 9.47 pg/1; mean after was 9.70 pg/1; P= 0.360). Furthermore, as compared with a group of normal, age-matched children (n =18), asthmatic children were found to have higher prechallenge levels of ECP (mean: 10.3 μg/1 compared with 26.3 μg/1) (P>0.001) and IL-2R (mean: 80.30 U/ml compared with 116.35 U/ml) (P =0.009), but not of IL-6 (mean: 11.34 pg/1 compared with 9.47 pg/1) (P = 0.436). A correlation was found between the duration of asthma and the severity of the LAR expressed as area under the curve (AUCLAR) (r = 0.50; P<0.040). Furthermore, a correlation was detected between the level of total IgE and the level of ECP (r = 0.51; P<0.030). The decrease in FEV1 during the LAR tended to correlate with the increase of IL-2R (r = 0.48; P = 0.050). This tendency was not found with the increase of eosinophils, nor with the increase of ECP. We conclude that both lymphocytes and eosinophils are activated by an allergen challenge, but that only the activation of lymphocytes tends to correlate with the LAR, suggesting that lymphocytes are also closely involved in the pathogenesis of the allergen-induced LAR." @default.
• W1999715467 created "2016-06-24" @default.
• W1999715467 creator A5012298568 @default.
• W1999715467 creator A5025241185 @default.
• W1999715467 creator A5041256007 @default.
• W1999715467 creator A5056266993 @default.
• W1999715467 creator A5067514986 @default.
• W1999715467 creator A5075880317 @default.
• W1999715467 creator A5079609914 @default.
• W1999715467 date "1993-08-01" @default.
• W1999715467 modified "2023-10-18" @default.
• W1999715467 title "Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble interleukin-2 receptor, and interleukin-6 in asthmatic children" @default.
• W1999715467 cites W1554535093 @default.
• W1999715467 cites W1592524646 @default.
• W1999715467 cites W1931895353 @default.
• W1999715467 cites W1971990400 @default.
• W1999715467 cites W1983413329 @default.
• W1999715467 cites W1992999867 @default.
• W1999715467 cites W1999933916 @default.
• W1999715467 cites W2008655039 @default.
• W1999715467 cites W2017013436 @default.
• W1999715467 cites W2024462345 @default.
• W1999715467 cites W2049507427 @default.
• W1999715467 cites W2065541586 @default.
• W1999715467 cites W2071754888 @default.
• W1999715467 cites W2075805277 @default.
• W1999715467 cites W2077887480 @default.
• W1999715467 cites W2078702130 @default.
• W1999715467 cites W2089367605 @default.
• W1999715467 cites W2116313488 @default.
• W1999715467 cites W2123928308 @default.
• W1999715467 cites W4247148213 @default.
• W1999715467 doi "https://doi.org/10.1111/j.1398-9995.1993.tb00742.x" @default.
• W1999715467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8238800" @default.
• W1999715467 hasPublicationYear "1993" @default.
• W1999715467 type Work @default.
• W1999715467 sameAs 1999715467 @default.
• W1999715467 citedByCount "11" @default.
• W1999715467 countsByYear W19997154672016 @default.
• W1999715467 countsByYear W19997154672022 @default.
• W1999715467 crossrefType "journal-article" @default.
• W1999715467 hasAuthorship W1999715467A5012298568 @default.
• W1999715467 hasAuthorship W1999715467A5025241185 @default.
• W1999715467 hasAuthorship W1999715467A5041256007 @default.
• W1999715467 hasAuthorship W1999715467A5056266993 @default.
• W1999715467 hasAuthorship W1999715467A5067514986 @default.
• W1999715467 hasAuthorship W1999715467A5075880317 @default.
• W1999715467 hasAuthorship W1999715467A5079609914 @default.
• W1999715467 hasConcept C110586980 @default.
• W1999715467 hasConcept C1122143 @default.
• W1999715467 hasConcept C126322002 @default.
• W1999715467 hasConcept C142724271 @default.
• W1999715467 hasConcept C181901479 @default.
• W1999715467 hasConcept C203014093 @default.
• W1999715467 hasConcept C204787440 @default.
• W1999715467 hasConcept C207480886 @default.
• W1999715467 hasConcept C2776042228 @default.
• W1999715467 hasConcept C2777037409 @default.
• W1999715467 hasConcept C2777129736 @default.
• W1999715467 hasConcept C2778166374 @default.
• W1999715467 hasConcept C2778690821 @default.
• W1999715467 hasConcept C2780510475 @default.
• W1999715467 hasConcept C43044207 @default.
• W1999715467 hasConcept C71924100 @default.
• W1999715467 hasConcept C74172505 @default.
• W1999715467 hasConcept C88675164 @default.
• W1999715467 hasConcept C90924648 @default.
• W1999715467 hasConceptScore W1999715467C110586980 @default.
• W1999715467 hasConceptScore W1999715467C1122143 @default.
• W1999715467 hasConceptScore W1999715467C126322002 @default.
• W1999715467 hasConceptScore W1999715467C142724271 @default.
• W1999715467 hasConceptScore W1999715467C181901479 @default.
• W1999715467 hasConceptScore W1999715467C203014093 @default.
• W1999715467 hasConceptScore W1999715467C204787440 @default.
• W1999715467 hasConceptScore W1999715467C207480886 @default.
• W1999715467 hasConceptScore W1999715467C2776042228 @default.
• W1999715467 hasConceptScore W1999715467C2777037409 @default.
• W1999715467 hasConceptScore W1999715467C2777129736 @default.
• W1999715467 hasConceptScore W1999715467C2778166374 @default.
• W1999715467 hasConceptScore W1999715467C2778690821 @default.
• W1999715467 hasConceptScore W1999715467C2780510475 @default.
• W1999715467 hasConceptScore W1999715467C43044207 @default.
• W1999715467 hasConceptScore W1999715467C71924100 @default.
• W1999715467 hasConceptScore W1999715467C74172505 @default.
• W1999715467 hasConceptScore W1999715467C88675164 @default.
• W1999715467 hasConceptScore W1999715467C90924648 @default.
• W1999715467 hasIssue "6" @default.
• W1999715467 hasLocation W19997154671 @default.
• W1999715467 hasLocation W19997154672 @default.
• W1999715467 hasOpenAccess W1999715467 @default.
• W1999715467 hasPrimaryLocation W19997154671 @default.
• W1999715467 hasRelatedWork W1554981735 @default.
• W1999715467 hasRelatedWork W1619172043 @default.
• W1999715467 hasRelatedWork W2046089283 @default.
• W1999715467 hasRelatedWork W2065084413 @default.
• W1999715467 hasRelatedWork W2075537437 @default.
• W1999715467 hasRelatedWork W2083087446 @default.
• W1999715467 hasRelatedWork W2348116141 @default.

• next