FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999718044> ?p ?o ?g. }

• W1999718044 endingPage "257" @default.
• W1999718044 startingPage "250" @default.
• W1999718044 abstract "At a low MOI (≤0.01), cytomegalovirus-associated programmed cell death terminates productive infection via a pathway triggered by the mitochondrial serine protease HtrA2/Omi. This infected cell death is associated with late phase replication events naturally suppressed by the viral mitochondrial inhibitor of apoptosis (vMIA). Here, higher MOI (ranging from 0.1-3.0) triggers cell death earlier during infection independent of viral DNA synthesis. Thus, MOI-dependent activating signals early, at high MOI, or late, at low MOI, during replication promote serine protease-dependent death that is suppressed by vMIA. Treatment with an antioxidant targeting reactive oxygen species (ROS) or the serine protease inhibitor N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) delays cell death, and the combination has an additive impact. These studies identify serine proteases and ROS as important factors triggering programmed cell death induced by vMIA-deficient virus, and show that this death pathway occurs earlier and reduces viral yields as the MOI is increased." @default.
• W1999718044 created "2016-06-24" @default.
• W1999718044 creator A5035976818 @default.
• W1999718044 creator A5037626712 @default.
• W1999718044 creator A5067097248 @default.
• W1999718044 creator A5077319683 @default.
• W1999718044 date "2013-01-01" @default.
• W1999718044 modified "2023-09-25" @default.
• W1999718044 title "Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway" @default.
• W1999718044 cites W1498940331 @default.
• W1999718044 cites W1965361052 @default.
• W1999718044 cites W1965703031 @default.
• W1999718044 cites W1974650890 @default.
• W1999718044 cites W1992643776 @default.
• W1999718044 cites W2003209587 @default.
• W1999718044 cites W2006961993 @default.
• W1999718044 cites W2008415530 @default.
• W1999718044 cites W2009958847 @default.
• W1999718044 cites W2011422973 @default.
• W1999718044 cites W2026419574 @default.
• W1999718044 cites W2028007570 @default.
• W1999718044 cites W2038401000 @default.
• W1999718044 cites W2040856926 @default.
• W1999718044 cites W2054776071 @default.
• W1999718044 cites W2060470131 @default.
• W1999718044 cites W2070423619 @default.
• W1999718044 cites W2076007552 @default.
• W1999718044 cites W2083574264 @default.
• W1999718044 cites W2084414744 @default.
• W1999718044 cites W2096939298 @default.
• W1999718044 cites W2107554012 @default.
• W1999718044 cites W2112256325 @default.
• W1999718044 cites W2113613608 @default.
• W1999718044 cites W2119570009 @default.
• W1999718044 cites W2122341467 @default.
• W1999718044 cites W2132025920 @default.
• W1999718044 cites W2142275651 @default.
• W1999718044 cites W2159702641 @default.
• W1999718044 cites W2160233843 @default.
• W1999718044 cites W2315484453 @default.
• W1999718044 doi "https://doi.org/10.1016/j.virol.2012.08.042" @default.
• W1999718044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3534952" @default.
• W1999718044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23159167" @default.
• W1999718044 hasPublicationYear "2013" @default.
• W1999718044 type Work @default.
• W1999718044 sameAs 1999718044 @default.
• W1999718044 citedByCount "14" @default.
• W1999718044 countsByYear W19997180442013 @default.
• W1999718044 countsByYear W19997180442014 @default.
• W1999718044 countsByYear W19997180442015 @default.
• W1999718044 countsByYear W19997180442020 @default.
• W1999718044 countsByYear W19997180442021 @default.
• W1999718044 countsByYear W19997180442023 @default.
• W1999718044 crossrefType "journal-article" @default.
• W1999718044 hasAuthorship W1999718044A5035976818 @default.
• W1999718044 hasAuthorship W1999718044A5037626712 @default.
• W1999718044 hasAuthorship W1999718044A5067097248 @default.
• W1999718044 hasAuthorship W1999718044A5077319683 @default.
• W1999718044 hasBestOaLocation W19997180441 @default.
• W1999718044 hasConcept C11960822 @default.
• W1999718044 hasConcept C140704245 @default.
• W1999718044 hasConcept C153911025 @default.
• W1999718044 hasConcept C159047783 @default.
• W1999718044 hasConcept C181199279 @default.
• W1999718044 hasConcept C182220744 @default.
• W1999718044 hasConcept C190283241 @default.
• W1999718044 hasConcept C203233990 @default.
• W1999718044 hasConcept C2522874641 @default.
• W1999718044 hasConcept C2776414213 @default.
• W1999718044 hasConcept C2776714187 @default.
• W1999718044 hasConcept C2777807008 @default.
• W1999718044 hasConcept C2909000736 @default.
• W1999718044 hasConcept C31573885 @default.
• W1999718044 hasConcept C55493867 @default.
• W1999718044 hasConcept C86803240 @default.
• W1999718044 hasConcept C95444343 @default.
• W1999718044 hasConceptScore W1999718044C11960822 @default.
• W1999718044 hasConceptScore W1999718044C140704245 @default.
• W1999718044 hasConceptScore W1999718044C153911025 @default.
• W1999718044 hasConceptScore W1999718044C159047783 @default.
• W1999718044 hasConceptScore W1999718044C181199279 @default.
• W1999718044 hasConceptScore W1999718044C182220744 @default.
• W1999718044 hasConceptScore W1999718044C190283241 @default.
• W1999718044 hasConceptScore W1999718044C203233990 @default.
• W1999718044 hasConceptScore W1999718044C2522874641 @default.
• W1999718044 hasConceptScore W1999718044C2776414213 @default.
• W1999718044 hasConceptScore W1999718044C2776714187 @default.
• W1999718044 hasConceptScore W1999718044C2777807008 @default.
• W1999718044 hasConceptScore W1999718044C2909000736 @default.
• W1999718044 hasConceptScore W1999718044C31573885 @default.
• W1999718044 hasConceptScore W1999718044C55493867 @default.
• W1999718044 hasConceptScore W1999718044C86803240 @default.
• W1999718044 hasConceptScore W1999718044C95444343 @default.
• W1999718044 hasIssue "2" @default.
• W1999718044 hasLocation W19997180441 @default.
• W1999718044 hasLocation W19997180442 @default.
• W1999718044 hasLocation W19997180443 @default.
• W1999718044 hasLocation W19997180444 @default.

• next