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- W1999719682 abstract "The precise function of ryanodine receptors (RyRs) in synaptic transmission is unknown, but three of their subtypes are expressed in the brain. We examined the roleof RyRs in excitatory synaptic transmission in hippocampalslices, using type 3 RyR (RyR3)-deficient mice. The α-amino-3-hydroxy-5-methyl-4-isoxozolepropionic acid (AMPA) receptor-mediated basal synaptic responses in the CA1 region of mutant mice were smaller than those of wild-type mice, while there wasno difference in N-methyl-d-aspartate receptor-mediated responses, suggesting selective postsynaptic modification of AMPA receptors by RyR3. The expression of synaptic AMPA receptor subunits examined by Western blotting or immunohistochemistry was indistinguishable,suggesting that the smaller AMPA synaptic responses in mutant mice were not due tothe reduced number of synaptic AMPA receptors. Although the initial potentiation following tetanic stimulation of afferent fibers was similar, long-term potentiation (LTP) was smaller in mutant mice. There were no differences in presynaptic electrophysiological properties. We thus conclude that RyR3 postsynaptically regulates the properties of AMPA receptors and LTP." @default.
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- W1999719682 date "2001-05-01" @default.
- W1999719682 modified "2023-10-01" @default.
- W1999719682 title "Postsynaptic Modulation of AMPA Receptor-Mediated Synaptic Responses and LTP by the Type 3 Ryanodine Receptor" @default.
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- W1999719682 doi "https://doi.org/10.1006/mcne.2001.0981" @default.
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