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• W1999723324 abstract "Specific serum and intestinal immunoglobulin (Ig)G1 and IgA responses to Heligmosomoides polygyrus were measured in a panel of seven inbred mouse strains which exhibit ‘rapid’ (< 6 weeks (SWR × SJL)F1), ‘fast’ (< 8 weeks, SJL and SWR), ‘intermediate’ (10–20 weeks, NIH and BALB/c) or ‘slow’ (> 25 weeks, C57BL/10 and CBA) resolution of primary infections. Mice with ‘rapid’, ‘fast’ or ‘intermediate’ response phenotypes produced greater serum and intestinal antibody responses than those with ‘slow’ phenotypes. The F1 hybrids ((SWR × SJL)F1) of two ‘fast’ responder strains showed the earliest antibody response with maximum titres evident within 6 weeks of infection. There was a negative correlation between the serum IgG1 responses and worm burdens in individual mice within a number of mouse strains, and also between serum IgG1 and IgA responses and worm burdens in the ‘rapid’ ((SWR × SJL)F1) responder strain. The presence of IgG1 in the gut was found to be due to local secretion rather than plasma leakage. Using Western immunoblotting, serum IgG1 from ‘rapid’ and ‘fast’ responder but not ‘slow’ responder mice was found to react with low molecular weight antigens (16–18 kDa) in adult worm excretory/secretory products." @default.
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• W1999723324 date "1999-08-01" @default.
• W1999723324 modified "2023-10-16" @default.
• W1999723324 title "The relationship between circulating and intestinal Heligmosomoides polygyrus-specific IgG1 and IgA and resistance to primary infection" @default.
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• W1999723324 doi "https://doi.org/10.1046/j.1365-3024.1999.00236.x" @default.
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