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• W1999726382 endingPage "2425" @default.
• W1999726382 startingPage "2413" @default.
• W1999726382 abstract "Although motor deficits are common in autism, the neural correlates underlying the disruption of even basic motor execution are unknown. Motor deficits may be some of the earliest identifiable signs of abnormal development and increased understanding of their neural underpinnings may provide insight into autism-associated differences in parallel systems critical for control of more complex behaviour necessary for social and communicative development. Functional magnetic resonance imaging was used to examine neural activation and connectivity during sequential, appositional finger tapping in 13 children, ages 8-12 years, with high-functioning autism (HFA) and 13 typically developing (TD), age- and sex-matched peers. Both groups showed expected primary activations in cortical and subcortical regions associated with motor execution [contralateral primary sensorimotor cortex, contralateral thalamus, ipsilateral cerebellum, supplementary motor area (SMA)]; however, the TD group showed greater activation in the ipsilateral anterior cerebellum, while the HFA group showed greater activation in the SMA. Although activation differences were limited to a subset of regions, children with HFA demonstrated diffusely decreased connectivity across the motor execution network relative to control children. The between-group dissociation of cerebral and cerebellar motor activation represents the first neuroimaging data of motor dysfunction in children with autism, providing insight into potentially abnormal circuits impacting development. Decreased cerebellar activation in the HFA group may reflect difficulty shifting motor execution from cortical regions associated with effortful control to regions associated with habitual execution. Additionally, diffusely decreased connectivity may reflect poor coordination within the circuit necessary for automating patterned motor behaviour. The findings might explain impairments in motor development in autism, as well as abnormal and delayed acquisition of gestures important for socialization and communication." @default.
• W1999726382 created "2016-06-24" @default.
• W1999726382 creator A5025787531 @default.
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• W1999726382 creator A5074044378 @default.
• W1999726382 date "2009-04-23" @default.
• W1999726382 modified "2023-10-17" @default.
• W1999726382 title "Decreased connectivity and cerebellar activity in autism during motor task performance" @default.
• W1999726382 cites W1541218738 @default.
• W1999726382 cites W1821241690 @default.
• W1999726382 cites W1899215478 @default.
• W1999726382 cites W1967127965 @default.
• W1999726382 cites W1968764578 @default.
• W1999726382 cites W1970357924 @default.
• W1999726382 cites W1970668016 @default.
• W1999726382 cites W1974400004 @default.
• W1999726382 cites W1974786952 @default.
• W1999726382 cites W1975317900 @default.
• W1999726382 cites W1976005699 @default.
• W1999726382 cites W1977370225 @default.
• W1999726382 cites W1980309199 @default.
• W1999726382 cites W1984965939 @default.
• W1999726382 cites W1987938015 @default.
• W1999726382 cites W1988440939 @default.
• W1999726382 cites W1993202958 @default.
• W1999726382 cites W1995168915 @default.
• W1999726382 cites W1996859891 @default.
• W1999726382 cites W2005072404 @default.
• W1999726382 cites W2005223615 @default.
• W1999726382 cites W2008035785 @default.
• W1999726382 cites W2009572025 @default.
• W1999726382 cites W2024107088 @default.
• W1999726382 cites W2024776041 @default.
• W1999726382 cites W2024805157 @default.
• W1999726382 cites W2026088138 @default.
• W1999726382 cites W2029590687 @default.
• W1999726382 cites W2030199728 @default.
• W1999726382 cites W2034625919 @default.
• W1999726382 cites W2038679877 @default.
• W1999726382 cites W2041334963 @default.
• W1999726382 cites W2041659565 @default.
• W1999726382 cites W2042999794 @default.
• W1999726382 cites W2044382973 @default.
• W1999726382 cites W2045619588 @default.
• W1999726382 cites W2048712654 @default.
• W1999726382 cites W2048998852 @default.
• W1999726382 cites W2050572297 @default.
• W1999726382 cites W2051674894 @default.
• W1999726382 cites W2054639804 @default.
• W1999726382 cites W2058923243 @default.
• W1999726382 cites W2058963528 @default.
• W1999726382 cites W2059558526 @default.
• W1999726382 cites W2066042950 @default.
• W1999726382 cites W2066396908 @default.
• W1999726382 cites W2067279040 @default.
• W1999726382 cites W2068258656 @default.
• W1999726382 cites W2071725411 @default.
• W1999726382 cites W2072166865 @default.
• W1999726382 cites W2075402838 @default.
• W1999726382 cites W2081722843 @default.
• W1999726382 cites W2082117755 @default.
• W1999726382 cites W2085851575 @default.
• W1999726382 cites W2086847281 @default.
• W1999726382 cites W2097589289 @default.
• W1999726382 cites W2097598293 @default.
• W1999726382 cites W2097745407 @default.
• W1999726382 cites W2101562854 @default.
• W1999726382 cites W2102726384 @default.
• W1999726382 cites W2109228085 @default.
• W1999726382 cites W2110528258 @default.
• W1999726382 cites W2111813237 @default.
• W1999726382 cites W2118780982 @default.
• W1999726382 cites W2127810520 @default.
• W1999726382 cites W2128359078 @default.
• W1999726382 cites W2130895133 @default.
• W1999726382 cites W2130913886 @default.
• W1999726382 cites W2130928858 @default.
• W1999726382 cites W2132092065 @default.
• W1999726382 cites W2133837044 @default.
• W1999726382 cites W2139399313 @default.
• W1999726382 cites W2144446993 @default.
• W1999726382 cites W2145439917 @default.
• W1999726382 cites W2146437136 @default.
• W1999726382 cites W2150005062 @default.
• W1999726382 cites W2154672996 @default.
• W1999726382 cites W2156390139 @default.
• W1999726382 cites W2156718278 @default.
• W1999726382 cites W2159813274 @default.
• W1999726382 cites W2162512585 @default.
• W1999726382 cites W2168456008 @default.
• W1999726382 cites W2168751917 @default.
• W1999726382 cites W2169285522 @default.
• W1999726382 cites W2172273794 @default.
• W1999726382 cites W2326708165 @default.
• W1999726382 cites W2889622349 @default.

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