FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999737726> ?p ?o ?g. }

• W1999737726 endingPage "F895" @default.
• W1999737726 startingPage "F886" @default.
• W1999737726 abstract "Lipid-mediated injury plays an important role in the pathogenesis of many renal diseases including diabetic nephropathy. Liver X receptor-alpha (LXRalpha) is an intracellular sterol sensor that regulates expression of genes controlling cholesterol absorption, excretion, catabolism, and cellular efflux. The present study was aimed at examining the role of LXRalpha in cholesterol metabolism in glomerular mesangial cells. A 1,561-bp fragment of full-length rabbit LXR cDNA was cloned. The deduced protein sequence exhibited 92.4 and 89.2% identity to human and mouse LXRalpha, respectively. Tissue distribution studies showed that rabbit LXRalpha was expressed in the liver, spleen, and kidney. In situ hybridization and RT-PCR assays further indicated that LXRalpha mRNA was widely expressed in the kidney and present in every nephron segment including the glomeruli. To determine intrarenal regulation of LXRalpha, rabbits were treated with thiazolidinedione (TZD) peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists, which have been previously shown to enhance LXRalpha expression via PPARgamma and increase cholesterol efflux in macrophages. The results showed that glomerular LXRalpha expression was markedly induced by TZDs. In cultured rabbit mesangial cells, LXRalpha mRNA and protein were detected by RT-PCR and immunoblotting. Treatment of mesangial cells with a specific LXRalpha agonist, TO-901317, significantly increased basal and apolipoprotein AI-mediated cholesterol efflux and markedly enhanced the promoter activity of an LXRalpha target gene, ATP-binding cassette transporter A1 (ABCA1). In conclusion, LXRalpha is expressed in renal glomeruli and functionally present in mesangial cells where its activation mediates cholesterol efflux via ABCA1. These data suggest that LXRalpha may be a potential therapeutic target for treating lipid-related renal glomerular disease." @default.
• W1999737726 created "2016-06-24" @default.
• W1999737726 creator A5000296373 @default.
• W1999737726 creator A5011110609 @default.
• W1999737726 creator A5019859590 @default.
• W1999737726 creator A5021769901 @default.
• W1999737726 creator A5033788719 @default.
• W1999737726 creator A5035819258 @default.
• W1999737726 creator A5037084131 @default.
• W1999737726 creator A5071722069 @default.
• W1999737726 creator A5091188597 @default.
• W1999737726 date "2004-11-01" @default.
• W1999737726 modified "2023-10-11" @default.
• W1999737726 title "Liver X receptor-α mediates cholesterol efflux in glomerular mesangial cells" @default.
• W1999737726 cites W1524478189 @default.
• W1999737726 cites W1812285428 @default.
• W1999737726 cites W1963713924 @default.
• W1999737726 cites W1968243232 @default.
• W1999737726 cites W1968631573 @default.
• W1999737726 cites W1974654697 @default.
• W1999737726 cites W1974711948 @default.
• W1999737726 cites W1985514124 @default.
• W1999737726 cites W1986256219 @default.
• W1999737726 cites W1987719260 @default.
• W1999737726 cites W2003798182 @default.
• W1999737726 cites W2008557193 @default.
• W1999737726 cites W2011154010 @default.
• W1999737726 cites W2015768468 @default.
• W1999737726 cites W2030207960 @default.
• W1999737726 cites W2032150705 @default.
• W1999737726 cites W2035838779 @default.
• W1999737726 cites W2040417680 @default.
• W1999737726 cites W2061865912 @default.
• W1999737726 cites W2074426271 @default.
• W1999737726 cites W2077155600 @default.
• W1999737726 cites W2081391060 @default.
• W1999737726 cites W2099603513 @default.
• W1999737726 cites W2101329987 @default.
• W1999737726 cites W2103487819 @default.
• W1999737726 cites W2104606103 @default.
• W1999737726 cites W2109938153 @default.
• W1999737726 cites W2112632255 @default.
• W1999737726 cites W2116814173 @default.
• W1999737726 cites W2124053881 @default.
• W1999737726 cites W2128003724 @default.
• W1999737726 cites W2128302560 @default.
• W1999737726 cites W2131752045 @default.
• W1999737726 cites W2133690273 @default.
• W1999737726 cites W2134367148 @default.
• W1999737726 cites W2145989568 @default.
• W1999737726 cites W2153673003 @default.
• W1999737726 cites W2159332620 @default.
• W1999737726 cites W2159425655 @default.
• W1999737726 cites W2159742257 @default.
• W1999737726 cites W2168300371 @default.
• W1999737726 cites W2171702365 @default.
• W1999737726 doi "https://doi.org/10.1152/ajprenal.00123.2004" @default.
• W1999737726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15280160" @default.
• W1999737726 hasPublicationYear "2004" @default.
• W1999737726 type Work @default.
• W1999737726 sameAs 1999737726 @default.
• W1999737726 citedByCount "53" @default.
• W1999737726 countsByYear W19997377262012 @default.
• W1999737726 countsByYear W19997377262013 @default.
• W1999737726 countsByYear W19997377262014 @default.
• W1999737726 countsByYear W19997377262015 @default.
• W1999737726 countsByYear W19997377262016 @default.
• W1999737726 countsByYear W19997377262017 @default.
• W1999737726 countsByYear W19997377262018 @default.
• W1999737726 countsByYear W19997377262019 @default.
• W1999737726 countsByYear W19997377262020 @default.
• W1999737726 countsByYear W19997377262021 @default.
• W1999737726 countsByYear W19997377262022 @default.
• W1999737726 crossrefType "journal-article" @default.
• W1999737726 hasAuthorship W1999737726A5000296373 @default.
• W1999737726 hasAuthorship W1999737726A5011110609 @default.
• W1999737726 hasAuthorship W1999737726A5019859590 @default.
• W1999737726 hasAuthorship W1999737726A5021769901 @default.
• W1999737726 hasAuthorship W1999737726A5033788719 @default.
• W1999737726 hasAuthorship W1999737726A5035819258 @default.
• W1999737726 hasAuthorship W1999737726A5037084131 @default.
• W1999737726 hasAuthorship W1999737726A5071722069 @default.
• W1999737726 hasAuthorship W1999737726A5091188597 @default.
• W1999737726 hasConcept C104317684 @default.
• W1999737726 hasConcept C110459506 @default.
• W1999737726 hasConcept C126322002 @default.
• W1999737726 hasConcept C134018914 @default.
• W1999737726 hasConcept C149011108 @default.
• W1999737726 hasConcept C167400880 @default.
• W1999737726 hasConcept C185592680 @default.
• W1999737726 hasConcept C2777704780 @default.
• W1999737726 hasConcept C2778163477 @default.
• W1999737726 hasConcept C2779131090 @default.
• W1999737726 hasConcept C2780072125 @default.
• W1999737726 hasConcept C2780091579 @default.
• W1999737726 hasConcept C55493867 @default.
• W1999737726 hasConcept C63932345 @default.
• W1999737726 hasConcept C71924100 @default.

• next