FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999742197> ?p ?o ?g. }

• W1999742197 endingPage "n/a" @default.
• W1999742197 startingPage "n/a" @default.
• W1999742197 abstract "Natural products, and their derivatives and mimics, have contributed to the development of important therapeutics to combat diseases such as infections and cancers over the past decades. The value of natural products to modern drug discovery is still considerable. However, its development is hampered by a lack of a mechanistic understanding of their molecular action, as opposed to the emerging molecule-targeted therapeutics that are tailored to a specific protein target(s). Recent advances in the mass spectrometry-based proteomic approaches have the potential to offer unprecedented insights into the molecular action of natural products. Chemical proteomics is established as an invaluable tool for the identification of protein targets of natural products. Small-molecule affinity selection combined with mass spectrometry is a successful strategy to “fish” cellular targets from the entire proteome. Mass spectrometry-based profiling of protein expression is also routinely employed to elucidate molecular pathways involved in the therapeutic and possible toxicological responses upon treatment with natural products. In addition, mass spectrometry is increasingly utilized to probe structural aspects of natural products–protein interactions. Limited proteolysis, photoaffinity labeling, and hydrogen/deuterium exchange in conjunction with mass spectrometry are sensitive and high-throughput strategies that provide low-resolution structural information of non-covalent natural product–protein complexes. In this review, we provide an overview on the applications of mass spectrometry-based techniques in the identification and characterization of natural product–protein interactions, and we describe how these applications might revolutionize natural product-based drug discovery. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:126–155, 2010" @default.
• W1999742197 created "2016-06-24" @default.
• W1999742197 creator A5012921461 @default.
• W1999742197 creator A5020167546 @default.
• W1999742197 creator A5039336343 @default.
• W1999742197 creator A5053483245 @default.
• W1999742197 creator A5083247881 @default.
• W1999742197 date "2009-01-01" @default.
• W1999742197 modified "2023-10-14" @default.
• W1999742197 title "Identification and characterization of molecular targets of natural products by mass spectrometry" @default.
• W1999742197 cites W1486583495 @default.
• W1999742197 cites W1639582946 @default.
• W1999742197 cites W1661993026 @default.
• W1999742197 cites W1964700940 @default.
• W1999742197 cites W1966183979 @default.
• W1999742197 cites W1966680901 @default.
• W1999742197 cites W1967879830 @default.
• W1999742197 cites W1968494166 @default.
• W1999742197 cites W1968782838 @default.
• W1999742197 cites W1969242164 @default.
• W1999742197 cites W1969249762 @default.
• W1999742197 cites W1970699966 @default.
• W1999742197 cites W1971121563 @default.
• W1999742197 cites W1971983473 @default.
• W1999742197 cites W1972770043 @default.
• W1999742197 cites W1973413944 @default.
• W1999742197 cites W1973483299 @default.
• W1999742197 cites W1973701839 @default.
• W1999742197 cites W1974112332 @default.
• W1999742197 cites W1974332498 @default.
• W1999742197 cites W1974478882 @default.
• W1999742197 cites W1975319432 @default.
• W1999742197 cites W1975599463 @default.
• W1999742197 cites W1976328109 @default.
• W1999742197 cites W1977675825 @default.
• W1999742197 cites W1978254752 @default.
• W1999742197 cites W1978443443 @default.
• W1999742197 cites W1978879981 @default.
• W1999742197 cites W1978964523 @default.
• W1999742197 cites W1979542564 @default.
• W1999742197 cites W1980078464 @default.
• W1999742197 cites W1980145652 @default.
• W1999742197 cites W1981050129 @default.
• W1999742197 cites W1981857444 @default.
• W1999742197 cites W1982058771 @default.
• W1999742197 cites W1982170669 @default.
• W1999742197 cites W1983186230 @default.
• W1999742197 cites W1983325108 @default.
• W1999742197 cites W1983489516 @default.
• W1999742197 cites W1985012670 @default.
• W1999742197 cites W1985038831 @default.
• W1999742197 cites W1985651425 @default.
• W1999742197 cites W1985692894 @default.
• W1999742197 cites W1986384924 @default.
• W1999742197 cites W1987041521 @default.
• W1999742197 cites W1987283802 @default.
• W1999742197 cites W1988633778 @default.
• W1999742197 cites W1991777486 @default.
• W1999742197 cites W1993919534 @default.
• W1999742197 cites W1994548505 @default.
• W1999742197 cites W1995371071 @default.
• W1999742197 cites W1995871306 @default.
• W1999742197 cites W1995901717 @default.
• W1999742197 cites W1996366920 @default.
• W1999742197 cites W1996512971 @default.
• W1999742197 cites W1996643987 @default.
• W1999742197 cites W1996826403 @default.
• W1999742197 cites W1997997916 @default.
• W1999742197 cites W1998392126 @default.
• W1999742197 cites W2001284390 @default.
• W1999742197 cites W2001720977 @default.
• W1999742197 cites W2002928661 @default.
• W1999742197 cites W2002946658 @default.
• W1999742197 cites W2003661795 @default.
• W1999742197 cites W2003940208 @default.
• W1999742197 cites W2004799012 @default.
• W1999742197 cites W2004845987 @default.
• W1999742197 cites W2007250004 @default.
• W1999742197 cites W2007326920 @default.
• W1999742197 cites W2007515181 @default.
• W1999742197 cites W2007783249 @default.
• W1999742197 cites W2008676938 @default.
• W1999742197 cites W2009298265 @default.
• W1999742197 cites W2009307924 @default.
• W1999742197 cites W2010112108 @default.
• W1999742197 cites W2010435021 @default.
• W1999742197 cites W2010844918 @default.
• W1999742197 cites W2012735248 @default.
• W1999742197 cites W2013024999 @default.
• W1999742197 cites W2013270869 @default.
• W1999742197 cites W2014615613 @default.
• W1999742197 cites W2015358023 @default.
• W1999742197 cites W2015667278 @default.
• W1999742197 cites W2016100084 @default.
• W1999742197 cites W2016707540 @default.
• W1999742197 cites W2017182293 @default.
• W1999742197 cites W2017898416 @default.
• W1999742197 cites W2017926405 @default.

• next