FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999744152> ?p ?o ?g. }

• W1999744152 endingPage "96" @default.
• W1999744152 startingPage "89" @default.
• W1999744152 abstract "Membrane-associated guanylate kinases (MAGUKs) are major components of the postsynaptic density and play important roles in synaptic organization and plasticity. Most excitatory synapses are located on dendritic spines, which are dynamic structures that undergo morphological changes during synapse formation and plasticity. Synapse-associated protein 102 (SAP102) is a MAGUK that is highly expressed early in development and mediates receptor trafficking during synaptogenesis. Mutations in human SAP102 cause mental retardation, which is often accompanied with abnormalities in dendritic spines. However, little is known about the role of SAP102 in regulating synapse formation or spine morphology. We now find that SAP102 contains a novel NMDA receptor binding site in the N-terminal domain, which is specific for the NR2B subunit. The interaction between SAP102 and NR2B is PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain independent and is regulated by alternative splicing of SAP102. We show that SAP102 that possesses an N-terminal insert is developmentally regulated at both mRNA and protein levels. In addition, expression of SAP102 increases synapse formation. Furthermore, the alternative splicing of SAP102 regulates dendritic spine morphology. SAP102 containing the N-terminal insert promotes lengthening of dendritic spines and preferentially promotes the formation of synapses at long spines, whereas a short hairpin RNA knockdown of the same SAP102 splice variant causes spine shrinkage. Finally, blocking NMDA receptor activity prevents the spine lengthening induced by the N-terminal splice variant of SAP102. Thus, our data provide the first evidence that SAP102 links NMDA receptor activation to alterations in spine morphology." @default.
• W1999744152 created "2016-06-24" @default.
• W1999744152 creator A5007550022 @default.
• W1999744152 creator A5036478363 @default.
• W1999744152 creator A5069750797 @default.
• W1999744152 creator A5071397864 @default.
• W1999744152 date "2011-01-05" @default.
• W1999744152 modified "2023-10-16" @default.
• W1999744152 title "NMDA Receptor-Dependent Regulation of Dendritic Spine Morphology by SAP102 Splice Variants" @default.
• W1999744152 cites W1487695731 @default.
• W1999744152 cites W1648575050 @default.
• W1999744152 cites W1653383134 @default.
• W1999744152 cites W1964258885 @default.
• W1999744152 cites W1964330366 @default.
• W1999744152 cites W1965670425 @default.
• W1999744152 cites W1970851711 @default.
• W1999744152 cites W1972012799 @default.
• W1999744152 cites W1977679299 @default.
• W1999744152 cites W1983199685 @default.
• W1999744152 cites W1983553517 @default.
• W1999744152 cites W1986246328 @default.
• W1999744152 cites W2001528712 @default.
• W1999744152 cites W2007018052 @default.
• W1999744152 cites W2027230597 @default.
• W1999744152 cites W2033793228 @default.
• W1999744152 cites W2036231188 @default.
• W1999744152 cites W2039132353 @default.
• W1999744152 cites W2044087866 @default.
• W1999744152 cites W2045895646 @default.
• W1999744152 cites W2047579925 @default.
• W1999744152 cites W2055345063 @default.
• W1999744152 cites W2059890547 @default.
• W1999744152 cites W2061895982 @default.
• W1999744152 cites W2062317659 @default.
• W1999744152 cites W2076357839 @default.
• W1999744152 cites W2077706363 @default.
• W1999744152 cites W2090319528 @default.
• W1999744152 cites W2093807579 @default.
• W1999744152 cites W2095421300 @default.
• W1999744152 cites W2097424141 @default.
• W1999744152 cites W2101875004 @default.
• W1999744152 cites W2103222728 @default.
• W1999744152 cites W2107611011 @default.
• W1999744152 cites W2131958615 @default.
• W1999744152 cites W2148714108 @default.
• W1999744152 cites W2149348969 @default.
• W1999744152 doi "https://doi.org/10.1523/jneurosci.1034-10.2011" @default.
• W1999744152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3030119" @default.
• W1999744152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209193" @default.
• W1999744152 hasPublicationYear "2011" @default.
• W1999744152 type Work @default.
• W1999744152 sameAs 1999744152 @default.
• W1999744152 citedByCount "46" @default.
• W1999744152 countsByYear W19997441522012 @default.
• W1999744152 countsByYear W19997441522013 @default.
• W1999744152 countsByYear W19997441522014 @default.
• W1999744152 countsByYear W19997441522015 @default.
• W1999744152 countsByYear W19997441522016 @default.
• W1999744152 countsByYear W19997441522017 @default.
• W1999744152 countsByYear W19997441522018 @default.
• W1999744152 countsByYear W19997441522019 @default.
• W1999744152 countsByYear W19997441522020 @default.
• W1999744152 countsByYear W19997441522021 @default.
• W1999744152 countsByYear W19997441522022 @default.
• W1999744152 crossrefType "journal-article" @default.
• W1999744152 hasAuthorship W1999744152A5007550022 @default.
• W1999744152 hasAuthorship W1999744152A5036478363 @default.
• W1999744152 hasAuthorship W1999744152A5069750797 @default.
• W1999744152 hasAuthorship W1999744152A5071397864 @default.
• W1999744152 hasBestOaLocation W19997441521 @default.
• W1999744152 hasConcept C127445978 @default.
• W1999744152 hasConcept C144647389 @default.
• W1999744152 hasConcept C148762608 @default.
• W1999744152 hasConcept C154428179 @default.
• W1999744152 hasConcept C169760540 @default.
• W1999744152 hasConcept C170493617 @default.
• W1999744152 hasConcept C172078151 @default.
• W1999744152 hasConcept C174884520 @default.
• W1999744152 hasConcept C187541742 @default.
• W1999744152 hasConcept C197341189 @default.
• W1999744152 hasConcept C41625074 @default.
• W1999744152 hasConcept C54355233 @default.
• W1999744152 hasConcept C67018056 @default.
• W1999744152 hasConcept C86803240 @default.
• W1999744152 hasConcept C95444343 @default.
• W1999744152 hasConcept C98229152 @default.
• W1999744152 hasConcept C99223954 @default.
• W1999744152 hasConceptScore W1999744152C127445978 @default.
• W1999744152 hasConceptScore W1999744152C144647389 @default.
• W1999744152 hasConceptScore W1999744152C148762608 @default.
• W1999744152 hasConceptScore W1999744152C154428179 @default.
• W1999744152 hasConceptScore W1999744152C169760540 @default.
• W1999744152 hasConceptScore W1999744152C170493617 @default.
• W1999744152 hasConceptScore W1999744152C172078151 @default.
• W1999744152 hasConceptScore W1999744152C174884520 @default.
• W1999744152 hasConceptScore W1999744152C187541742 @default.
• W1999744152 hasConceptScore W1999744152C197341189 @default.
• W1999744152 hasConceptScore W1999744152C41625074 @default.

• next