FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999756883> ?p ?o ?g. }

• W1999756883 endingPage "1644" @default.
• W1999756883 startingPage "1636" @default.
• W1999756883 abstract "Transforming growth factor (TGF)-beta is a cytokine that has been demonstrated to be an important modulator of inflammation and angiogenesis, as well as a potent stimulator of pleural fluid production and fibrosis. We previously demonstrated that rising levels of pleural fluid TGF-beta(1) correlate with pleural fibrosis in experimental empyema in rabbits. In this study, our hypothesis is that neutralization of TGF-beta with an intrapleural injection of a monoclonal antibody to TGF-beta will decrease pleural fibrosis in empyema.Prospective, randomized, blinded study.Animal research laboratory.Nineteen rabbits.An empyema was induced in 19 rabbits by intrapleural injection of Pasteurella multocida. A panspecific monoclonal antibody to TGF-beta was injected into the pleural space on 2 subsequent concurrent days in nine rabbits. Ten rabbits received intrapleural injections of bacteria alone and served as controls. All animals were then killed on day 6. Immunohistochemistry, using the antibody to TGF-beta, was performed on pleural tissue specimens from the control rabbits.Immunohistochemistry revealed localization of TGF-beta to macrophages in the exudative material and the visceral pleura. After injection of the antibody to TGF-beta, the amount of purulent, exudative material in the pleural space of the nine experimental animals was markedly decreased at autopsy on day 6, relative to control animals. All markers of empyema and pleural fibrosis were also significantly decreased in the rabbits receiving intrapleural anti-TGF-beta.TGF-beta localizes to macrophages in experimental empyema. Early intrapleural injection of an antibody to TGF-beta inhibits empyema formation and significantly decreases pleural fibrosis in experimental empyema." @default.
• W1999756883 created "2016-06-24" @default.
• W1999756883 creator A5014446845 @default.
• W1999756883 creator A5023125446 @default.
• W1999756883 creator A5039356359 @default.
• W1999756883 creator A5041929692 @default.
• W1999756883 creator A5048224604 @default.
• W1999756883 creator A5078352962 @default.
• W1999756883 date "2004-11-01" @default.
• W1999756883 modified "2023-10-05" @default.
• W1999756883 title "Intrapleural Injection of Transforming Growth Factor-β Antibody Inhibits Pleural Fibrosis in Empyema" @default.
• W1999756883 cites W152476411 @default.
• W1999756883 cites W1976001496 @default.
• W1999756883 cites W1991580413 @default.
• W1999756883 cites W1993851092 @default.
• W1999756883 cites W1996104198 @default.
• W1999756883 cites W2008386546 @default.
• W1999756883 cites W2017096535 @default.
• W1999756883 cites W2025620210 @default.
• W1999756883 cites W2027162482 @default.
• W1999756883 cites W2029144169 @default.
• W1999756883 cites W2037753264 @default.
• W1999756883 cites W2043461395 @default.
• W1999756883 cites W2046256446 @default.
• W1999756883 cites W2046772390 @default.
• W1999756883 cites W2048674833 @default.
• W1999756883 cites W2048700660 @default.
• W1999756883 cites W2060928333 @default.
• W1999756883 cites W2064751148 @default.
• W1999756883 cites W2068797496 @default.
• W1999756883 cites W2091721680 @default.
• W1999756883 cites W2092934529 @default.
• W1999756883 cites W2099941826 @default.
• W1999756883 cites W2100182742 @default.
• W1999756883 cites W2100970629 @default.
• W1999756883 cites W2124703574 @default.
• W1999756883 cites W2126762280 @default.
• W1999756883 cites W2128571355 @default.
• W1999756883 cites W2129965949 @default.
• W1999756883 cites W2138605058 @default.
• W1999756883 cites W2168565164 @default.
• W1999756883 cites W2217868403 @default.
• W1999756883 cites W2335187016 @default.
• W1999756883 cites W4246821720 @default.
• W1999756883 cites W4376595568 @default.
• W1999756883 doi "https://doi.org/10.1378/chest.126.5.1636" @default.
• W1999756883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15539738" @default.
• W1999756883 hasPublicationYear "2004" @default.
• W1999756883 type Work @default.
• W1999756883 sameAs 1999756883 @default.
• W1999756883 citedByCount "31" @default.
• W1999756883 countsByYear W19997568832012 @default.
• W1999756883 countsByYear W19997568832014 @default.
• W1999756883 countsByYear W19997568832015 @default.
• W1999756883 countsByYear W19997568832016 @default.
• W1999756883 countsByYear W19997568832017 @default.
• W1999756883 countsByYear W19997568832018 @default.
• W1999756883 countsByYear W19997568832019 @default.
• W1999756883 countsByYear W19997568832020 @default.
• W1999756883 countsByYear W19997568832021 @default.
• W1999756883 countsByYear W19997568832022 @default.
• W1999756883 countsByYear W19997568832023 @default.
• W1999756883 crossrefType "journal-article" @default.
• W1999756883 hasAuthorship W1999756883A5014446845 @default.
• W1999756883 hasAuthorship W1999756883A5023125446 @default.
• W1999756883 hasAuthorship W1999756883A5039356359 @default.
• W1999756883 hasAuthorship W1999756883A5041929692 @default.
• W1999756883 hasAuthorship W1999756883A5048224604 @default.
• W1999756883 hasAuthorship W1999756883A5078352962 @default.
• W1999756883 hasConcept C126322002 @default.
• W1999756883 hasConcept C142724271 @default.
• W1999756883 hasConcept C159654299 @default.
• W1999756883 hasConcept C203014093 @default.
• W1999756883 hasConcept C204232928 @default.
• W1999756883 hasConcept C2776178081 @default.
• W1999756883 hasConcept C2776517811 @default.
• W1999756883 hasConcept C2777714996 @default.
• W1999756883 hasConcept C2777799383 @default.
• W1999756883 hasConcept C2778690821 @default.
• W1999756883 hasConcept C2780559512 @default.
• W1999756883 hasConcept C71924100 @default.
• W1999756883 hasConceptScore W1999756883C126322002 @default.
• W1999756883 hasConceptScore W1999756883C142724271 @default.
• W1999756883 hasConceptScore W1999756883C159654299 @default.
• W1999756883 hasConceptScore W1999756883C203014093 @default.
• W1999756883 hasConceptScore W1999756883C204232928 @default.
• W1999756883 hasConceptScore W1999756883C2776178081 @default.
• W1999756883 hasConceptScore W1999756883C2776517811 @default.
• W1999756883 hasConceptScore W1999756883C2777714996 @default.
• W1999756883 hasConceptScore W1999756883C2777799383 @default.
• W1999756883 hasConceptScore W1999756883C2778690821 @default.
• W1999756883 hasConceptScore W1999756883C2780559512 @default.
• W1999756883 hasConceptScore W1999756883C71924100 @default.
• W1999756883 hasIssue "5" @default.
• W1999756883 hasLocation W19997568831 @default.
• W1999756883 hasLocation W19997568832 @default.
• W1999756883 hasOpenAccess W1999756883 @default.
• W1999756883 hasPrimaryLocation W19997568831 @default.

• next