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- W1999759577 abstract "Research on prevention of tuberculosis in people with HIV is an active specialty, with varying and often contradictory results from clinical trials. A systematic review 1 Akolo C Adetifa I Shepperd S Volmink J Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2010; 20 (CD000171) Google Scholar of ten trials showed that treatment of latent tuberculosis infection in people with HIV not on antiretroviral treatment lowered the risk of tuberculosis by a weighted average of 62% in people who had a positive tuberculin skin test, 11% with a negative test, and 38% overall. However, the studies were heterogeneous in terms of duration of isoniazid preventive therapy and follow-up, with varying degrees of efficacy. Although WHO recommends the use of isoniazid preventive therapy (along with intensified case finding and infection control) in people with HIV to reduce incidence of tuberculosis, evidence about its benefit in individuals on antiretroviral treatment is scarce. 2 WHOWHO three I's meeting report. Intensified case finding (ICF), Isoniazid preventive therapy (IPT) and TB infection control (IC) for people living with HIV. World Health Organization Press, Geneva2008 Google Scholar Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trialWithout a more predictive test or a multivariate algorithm that predicts benefit, isoniazid preventive therapy should be recommended to all patients receiving antiretroviral therapy in moderate or high incidence areas irrespective of tuberculin skin test or interferon gamma release assay status. Full-Text PDF" @default.
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- W1999759577 date "2014-08-01" @default.
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- W1999759577 title "Preventive treatment for tuberculosis in people with HIV" @default.
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- W1999759577 doi "https://doi.org/10.1016/s0140-6736(14)60268-3" @default.
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