Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999761427> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1999761427 endingPage "677" @default.
- W1999761427 startingPage "672" @default.
- W1999761427 abstract "<h2>Abstract</h2> In an effort to determine whether the beneficial effect of calcium blocking drugs occurs only during ischemia or during reperfusion as well, anesthetized dogs were subjected to 3 hours of occlusion of the left anterior descending coronary artery followed by 3 hours of reperfusion. In protocol A, intracoronary verapamil (0.01 mg/kg/min) was begun 90 minutes after coronary occlusion and continued for 1 hour into the reperfusion phase (n = 6) while a control group received an infusion of saline solution (n = 6). In vivo area at risk determined by dye injection was 29 ± 3% of the left ventricle (± standard error of the mean) in the control group and 30 ± 3% in the verapamil group (difference not significant [NS]), whereas the area of necrosis determined by triphenyltetrazolium staining and expressed as a percent of area at risk was smaller in the verapamil group (29 ± 8%) than in the control group (57 ± 8%, p <0.05). In protocol B, verapamil infusion into the left anterior descending coronary was begun 5 minutes before blood reperfusion and continued throughout the 3-hour reperfusion phase. Area at risk was similar in both groups (control, 25 ± 1%, n=8; verapamil, 28 ± 2%, n=8, NS); area of necrosis expressed as a percentage of area at risk was 49 ± 6% in the control group and 45 ± 10% in the verapamil group (NS). Therefore, calcium blockade of ischemic myocytes delays death and enhances salvage produced by reperfusion. However, calcium blockade begun after prolonged coronary occlusion does not enhance reperfusion-induced myocardial salvage." @default.
- W1999761427 created "2016-06-24" @default.
- W1999761427 creator A5015839705 @default.
- W1999761427 creator A5037967058 @default.
- W1999761427 creator A5043533532 @default.
- W1999761427 date "1985-10-01" @default.
- W1999761427 modified "2023-09-27" @default.
- W1999761427 title "Effect of intracoronary verapamil on infarct size in the ischemic, reperfused canine heart: Critical importance of the timing of treatment" @default.
- W1999761427 cites W1549544521 @default.
- W1999761427 cites W1964756027 @default.
- W1999761427 cites W1971054363 @default.
- W1999761427 cites W1979884480 @default.
- W1999761427 cites W1980454176 @default.
- W1999761427 cites W1991117742 @default.
- W1999761427 cites W1993082552 @default.
- W1999761427 cites W1994054757 @default.
- W1999761427 cites W1998949580 @default.
- W1999761427 cites W2004985101 @default.
- W1999761427 cites W2005287643 @default.
- W1999761427 cites W2018068332 @default.
- W1999761427 cites W2026570765 @default.
- W1999761427 cites W2039331543 @default.
- W1999761427 cites W2041251884 @default.
- W1999761427 cites W2045257946 @default.
- W1999761427 cites W2048268033 @default.
- W1999761427 cites W2048278013 @default.
- W1999761427 cites W2071188583 @default.
- W1999761427 cites W2087552099 @default.
- W1999761427 cites W2090939675 @default.
- W1999761427 cites W2133680772 @default.
- W1999761427 cites W2151492304 @default.
- W1999761427 cites W2164046218 @default.
- W1999761427 cites W2326758534 @default.
- W1999761427 doi "https://doi.org/10.1016/0002-9149(85)91033-1" @default.
- W1999761427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4050705" @default.
- W1999761427 hasPublicationYear "1985" @default.
- W1999761427 type Work @default.
- W1999761427 sameAs 1999761427 @default.
- W1999761427 citedByCount "73" @default.
- W1999761427 countsByYear W19997614272013 @default.
- W1999761427 countsByYear W19997614272016 @default.
- W1999761427 countsByYear W19997614272017 @default.
- W1999761427 crossrefType "journal-article" @default.
- W1999761427 hasAuthorship W1999761427A5015839705 @default.
- W1999761427 hasAuthorship W1999761427A5037967058 @default.
- W1999761427 hasAuthorship W1999761427A5043533532 @default.
- W1999761427 hasConcept C126322002 @default.
- W1999761427 hasConcept C164705383 @default.
- W1999761427 hasConcept C2776268601 @default.
- W1999761427 hasConcept C2777022698 @default.
- W1999761427 hasConcept C2777397205 @default.
- W1999761427 hasConcept C2778921608 @default.
- W1999761427 hasConcept C2780393670 @default.
- W1999761427 hasConcept C42219234 @default.
- W1999761427 hasConcept C519063684 @default.
- W1999761427 hasConcept C541997718 @default.
- W1999761427 hasConcept C71924100 @default.
- W1999761427 hasConcept C85520022 @default.
- W1999761427 hasConceptScore W1999761427C126322002 @default.
- W1999761427 hasConceptScore W1999761427C164705383 @default.
- W1999761427 hasConceptScore W1999761427C2776268601 @default.
- W1999761427 hasConceptScore W1999761427C2777022698 @default.
- W1999761427 hasConceptScore W1999761427C2777397205 @default.
- W1999761427 hasConceptScore W1999761427C2778921608 @default.
- W1999761427 hasConceptScore W1999761427C2780393670 @default.
- W1999761427 hasConceptScore W1999761427C42219234 @default.
- W1999761427 hasConceptScore W1999761427C519063684 @default.
- W1999761427 hasConceptScore W1999761427C541997718 @default.
- W1999761427 hasConceptScore W1999761427C71924100 @default.
- W1999761427 hasConceptScore W1999761427C85520022 @default.
- W1999761427 hasIssue "10" @default.
- W1999761427 hasLocation W19997614271 @default.
- W1999761427 hasLocation W19997614272 @default.
- W1999761427 hasOpenAccess W1999761427 @default.
- W1999761427 hasPrimaryLocation W19997614271 @default.
- W1999761427 hasRelatedWork W2025590009 @default.
- W1999761427 hasRelatedWork W2036496743 @default.
- W1999761427 hasRelatedWork W2095936650 @default.
- W1999761427 hasRelatedWork W2125122147 @default.
- W1999761427 hasRelatedWork W2168953710 @default.
- W1999761427 hasRelatedWork W2400096344 @default.
- W1999761427 hasRelatedWork W2625559747 @default.
- W1999761427 hasRelatedWork W2969904132 @default.
- W1999761427 hasRelatedWork W3142991939 @default.
- W1999761427 hasRelatedWork W1998263983 @default.
- W1999761427 hasVolume "56" @default.
- W1999761427 isParatext "false" @default.
- W1999761427 isRetracted "false" @default.
- W1999761427 magId "1999761427" @default.
- W1999761427 workType "article" @default.