FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999766340> ?p ?o ?g. }

• W1999766340 endingPage "268" @default.
• W1999766340 startingPage "257" @default.
• W1999766340 abstract "For many years the neuromodulator adenosine has been recognized as an endogenous anticonvulsant molecule and termed a “retaliatory metabolite.” As the core molecule of ATP, adenosine forms a unique link between cell energy and neuronal excitability. In parallel, a ketogenic (high-fat, low-carbohydrate) diet is a metabolic therapy that influences neuronal activity significantly, and ketogenic diets have been used successfully to treat medically-refractory epilepsy, particularly in children, for decades. To date the key neural mechanisms underlying the success of dietary therapy are unclear, hindering development of analogous pharmacological solutions. Similarly, adenosine receptor – based therapies for epilepsy and myriad other disorders remain elusive. In this review we explore the physiological regulation of adenosine as an anticonvulsant strategy and suggest a critical role for adenosine in the success of ketogenic diet therapy for epilepsy. While the current focus is on the regulation of adenosine, ketogenic metabolism and epilepsy, the therapeutic implications extend to acute and chronic neurological disorders as diverse as brain injury, inflammatory and neuropathic pain, autism and hyperdopaminergic disorders. Emerging evidence for broad clinical relevance of the metabolic regulation of adenosine will be discussed. Keywords: Metabolism, neuroprotection, neurodegeneration, sleep, pain, autism, addiction, dopamine" @default.
• W1999766340 created "2016-06-24" @default.
• W1999766340 creator A5018391871 @default.
• W1999766340 creator A5058454077 @default.
• W1999766340 creator A5076245773 @default.
• W1999766340 creator A5086250751 @default.
• W1999766340 creator A5090373938 @default.
• W1999766340 date "2009-09-01" @default.
• W1999766340 modified "2023-09-30" @default.
• W1999766340 title "Adenosine, Ketogenic Diet and Epilepsy: The Emerging Therapeutic Relationship Between Metabolism and Brain Activity" @default.
• W1999766340 cites W1488197968 @default.
• W1999766340 cites W1488748351 @default.
• W1999766340 cites W1528076766 @default.
• W1999766340 cites W1545781466 @default.
• W1999766340 cites W1551550807 @default.
• W1999766340 cites W1553706460 @default.
• W1999766340 cites W1571545340 @default.
• W1999766340 cites W1604113931 @default.
• W1999766340 cites W1626523363 @default.
• W1999766340 cites W1653077694 @default.
• W1999766340 cites W1749911542 @default.
• W1999766340 cites W1759750343 @default.
• W1999766340 cites W1936310758 @default.
• W1999766340 cites W1939145972 @default.
• W1999766340 cites W1948580858 @default.
• W1999766340 cites W1963764925 @default.
• W1999766340 cites W1965095084 @default.
• W1999766340 cites W1965509369 @default.
• W1999766340 cites W1966556786 @default.
• W1999766340 cites W1966761144 @default.
• W1999766340 cites W1967751240 @default.
• W1999766340 cites W1968301957 @default.
• W1999766340 cites W1968443196 @default.
• W1999766340 cites W1968798976 @default.
• W1999766340 cites W1969220135 @default.
• W1999766340 cites W1969275215 @default.
• W1999766340 cites W1970226275 @default.
• W1999766340 cites W1970892256 @default.
• W1999766340 cites W1973133262 @default.
• W1999766340 cites W1973313636 @default.
• W1999766340 cites W1975332428 @default.
• W1999766340 cites W1976627644 @default.
• W1999766340 cites W1976710020 @default.
• W1999766340 cites W1980355815 @default.
• W1999766340 cites W1982363194 @default.
• W1999766340 cites W1982473707 @default.
• W1999766340 cites W1982734210 @default.
• W1999766340 cites W1982797737 @default.
• W1999766340 cites W1983699965 @default.
• W1999766340 cites W1984813277 @default.
• W1999766340 cites W1985060509 @default.
• W1999766340 cites W1987140385 @default.
• W1999766340 cites W1989944353 @default.
• W1999766340 cites W1990349540 @default.
• W1999766340 cites W1993295644 @default.
• W1999766340 cites W1995941325 @default.
• W1999766340 cites W1997608954 @default.
• W1999766340 cites W1997788251 @default.
• W1999766340 cites W1997887740 @default.
• W1999766340 cites W1999116988 @default.
• W1999766340 cites W2001821357 @default.
• W1999766340 cites W2002665840 @default.
• W1999766340 cites W2002895429 @default.
• W1999766340 cites W2003496148 @default.
• W1999766340 cites W2003557216 @default.
• W1999766340 cites W2003975764 @default.
• W1999766340 cites W2006689411 @default.
• W1999766340 cites W2008041264 @default.
• W1999766340 cites W2008731937 @default.
• W1999766340 cites W2008736288 @default.
• W1999766340 cites W2009591333 @default.
• W1999766340 cites W2011578117 @default.
• W1999766340 cites W2012249601 @default.
• W1999766340 cites W2012462745 @default.
• W1999766340 cites W2012553932 @default.
• W1999766340 cites W2013486761 @default.
• W1999766340 cites W2013890548 @default.
• W1999766340 cites W2015337493 @default.
• W1999766340 cites W2015492904 @default.
• W1999766340 cites W2016730058 @default.
• W1999766340 cites W2018160227 @default.
• W1999766340 cites W2018361770 @default.
• W1999766340 cites W2021727710 @default.
• W1999766340 cites W2023210005 @default.
• W1999766340 cites W2023983971 @default.
• W1999766340 cites W2024748283 @default.
• W1999766340 cites W2026437921 @default.
• W1999766340 cites W2027024374 @default.
• W1999766340 cites W2029045430 @default.
• W1999766340 cites W2030905853 @default.
• W1999766340 cites W2032121387 @default.
• W1999766340 cites W2033456548 @default.
• W1999766340 cites W2034324747 @default.
• W1999766340 cites W2040252515 @default.
• W1999766340 cites W2040473331 @default.
• W1999766340 cites W2041023794 @default.
• W1999766340 cites W2041292257 @default.
• W1999766340 cites W2041421668 @default.

• next