Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999774433> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1999774433 endingPage "9825" @default.
- W1999774433 startingPage "9820" @default.
- W1999774433 abstract "A series of crown boronic acids, 1−4, were synthesized and studied as carriers for catecholamine transport through bulk liquid membranes (BLMs) and supported liquid membranes (SLMs). Carrier 1 greatly facilitated the transport of primary catecholamines through BLMs; whereas, the more lipophilic analogues 3 and 4 were less effective. A combination of kinetic, mass spectral, and NMR evidence suggests that the transported species in BLMs is the cyclic, zwitterionic, 1:1 complex 7. The SLM transport studies used a liquid membrane of 2-nitrophenyl octyl ether supported by a thin, flat sheet of porous polypropylene. In the absence of carrier there was neglible dopamine transport (<5 × 10-9 mol/m2·s) at pH 7.2. When the membrane contained carrier 3 (33 mM or about 2% wt), facilitated catecholamine transport was observed in the order of dopamine (5 × 10-7 mol/m2·s) > epinephrine (1.5 × 10-7 mol/m2·s) > norepinephrine (0.8 × 10-7 mol/m2·s). SLMs containing carrier 3 were stable, implying that carrier 3 is a very good candidate for transport mechanism studies. Crown boronic acid 4 was an even better transport carrier of primary catecholamines with a transport order of norepinephrine (4.7 × 10-6 mol/m2·s) > dopamine (3.5 × 10-6 mol/m2·s) ≫ epinephrine (3 × 10-8 mol/m2·s). It is 10 times more effective than an equimolar mixture of boronic acid 5 and crown 6, which is one of best examples of ditopic cooperativity yet observed in SLM transport. SLMs containing 4, however, did not exibit long-term stability. Overall, it is possible that a device based on SLMs containing crown boronic acid carriers can be developed to selectively extract catecholamines from clinical samples." @default.
- W1999774433 created "2016-06-24" @default.
- W1999774433 creator A5004750404 @default.
- W1999774433 creator A5014762863 @default.
- W1999774433 creator A5031572002 @default.
- W1999774433 creator A5037381205 @default.
- W1999774433 creator A5045120040 @default.
- W1999774433 creator A5072628812 @default.
- W1999774433 date "1996-01-01" @default.
- W1999774433 modified "2023-10-16" @default.
- W1999774433 title "Facilitated Catecholamine Transport through Bulk and Polymer-Supported Liquid Membranes" @default.
- W1999774433 cites W1942233577 @default.
- W1999774433 cites W1983783428 @default.
- W1999774433 cites W2000732584 @default.
- W1999774433 cites W2017965328 @default.
- W1999774433 cites W2039115227 @default.
- W1999774433 cites W2091241825 @default.
- W1999774433 cites W2170383296 @default.
- W1999774433 doi "https://doi.org/10.1021/ja9615076" @default.
- W1999774433 hasPublicationYear "1996" @default.
- W1999774433 type Work @default.
- W1999774433 sameAs 1999774433 @default.
- W1999774433 citedByCount "71" @default.
- W1999774433 countsByYear W19997744332012 @default.
- W1999774433 countsByYear W19997744332013 @default.
- W1999774433 countsByYear W19997744332014 @default.
- W1999774433 countsByYear W19997744332015 @default.
- W1999774433 countsByYear W19997744332022 @default.
- W1999774433 crossrefType "journal-article" @default.
- W1999774433 hasAuthorship W1999774433A5004750404 @default.
- W1999774433 hasAuthorship W1999774433A5014762863 @default.
- W1999774433 hasAuthorship W1999774433A5031572002 @default.
- W1999774433 hasAuthorship W1999774433A5037381205 @default.
- W1999774433 hasAuthorship W1999774433A5045120040 @default.
- W1999774433 hasAuthorship W1999774433A5072628812 @default.
- W1999774433 hasBestOaLocation W19997744332 @default.
- W1999774433 hasConcept C126322002 @default.
- W1999774433 hasConcept C127413603 @default.
- W1999774433 hasConcept C178790620 @default.
- W1999774433 hasConcept C184651966 @default.
- W1999774433 hasConcept C185592680 @default.
- W1999774433 hasConcept C205066982 @default.
- W1999774433 hasConcept C2775894120 @default.
- W1999774433 hasConcept C41625074 @default.
- W1999774433 hasConcept C42360764 @default.
- W1999774433 hasConcept C55493867 @default.
- W1999774433 hasConcept C71924100 @default.
- W1999774433 hasConceptScore W1999774433C126322002 @default.
- W1999774433 hasConceptScore W1999774433C127413603 @default.
- W1999774433 hasConceptScore W1999774433C178790620 @default.
- W1999774433 hasConceptScore W1999774433C184651966 @default.
- W1999774433 hasConceptScore W1999774433C185592680 @default.
- W1999774433 hasConceptScore W1999774433C205066982 @default.
- W1999774433 hasConceptScore W1999774433C2775894120 @default.
- W1999774433 hasConceptScore W1999774433C41625074 @default.
- W1999774433 hasConceptScore W1999774433C42360764 @default.
- W1999774433 hasConceptScore W1999774433C55493867 @default.
- W1999774433 hasConceptScore W1999774433C71924100 @default.
- W1999774433 hasIssue "41" @default.
- W1999774433 hasLocation W19997744331 @default.
- W1999774433 hasLocation W19997744332 @default.
- W1999774433 hasOpenAccess W1999774433 @default.
- W1999774433 hasPrimaryLocation W19997744331 @default.
- W1999774433 hasRelatedWork W1979156653 @default.
- W1999774433 hasRelatedWork W1997484252 @default.
- W1999774433 hasRelatedWork W2016248653 @default.
- W1999774433 hasRelatedWork W2027769984 @default.
- W1999774433 hasRelatedWork W2249456921 @default.
- W1999774433 hasRelatedWork W2322326441 @default.
- W1999774433 hasRelatedWork W2353300876 @default.
- W1999774433 hasRelatedWork W2517643257 @default.
- W1999774433 hasRelatedWork W4313070989 @default.
- W1999774433 hasRelatedWork W4319782397 @default.
- W1999774433 hasVolume "118" @default.
- W1999774433 isParatext "false" @default.
- W1999774433 isRetracted "false" @default.
- W1999774433 magId "1999774433" @default.
- W1999774433 workType "article" @default.