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• W1999813198 abstract "You have accessJournal of UrologyAdrenal: Surgery/Tumors/Benign and Malignant Disease1 Apr 201030 OUTCOMES OF PARTIAL ADRENALECTOMY FOR PHEOCHROMOCYTOMA IN VHL PATIENTS AFTER AT LEAST 5 YEARS OF FOLLOW UP Jihane N. Benhammou, Ronald S. Boris, W. Marston Linehan, Peter A. Pinto, and Gennady Bratslavsky Jihane N. BenhammouJihane N. Benhammou More articles by this author , Ronald S. BorisRonald S. Boris More articles by this author , W. Marston LinehanW. Marston Linehan More articles by this author , Peter A. PintoPeter A. Pinto More articles by this author , and Gennady BratslavskyGennady Bratslavsky More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.074AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Adrenal-sparing surgery can be performed for pheochromocytoma in a majority of patients with Von Hippel-Lindau (VHL) to preserve adrenal function and minimize long-term steroid replacement therapy. Although safety and feasibility of partial adrenalectomy has been established, long-term outcomes in this patient population has not been examined. We present recurrence and functional outcomes of a VHL cohort treated for pheochromocytoma with partial adrenalectomy with a follow up of at least 5 years. METHODS We retrospectively reviewed records of VHL patients undergoing partial adrenalectomy for pheochromocytoma. Demographics, indications for surgery, surgical approach, recurrence and functional outcome data were collected. Local recurrence was defined as radiographic evidence of recurrent tumor on the ipsilateral side of partial adrenalectomy. Patients were considered steroid-dependent if they required steroids at last follow up. RESULTS Twenty-seven VHL patients underwent 36 partial adrenalectomies for pheochromocytoma between September 1995 and November 2004 at the National Institutes of Health. Twenty-three cases were performed open and 13 laparoscopically. Partial adrenalectomy was completed in all instances. All tumors were confined to the tumor capsule. At a median of 9.8 years (5-14 years) of follow up, no patients have developed metastatic pheochromocytoma. Two patients developed local recurrence both of which underwent repeat partial adrenalectomy. Both recurrences were detected by CT and neither patient had symptoms. Additionally, 3 of 27 patients (11%) subsequently required partial adrenalectomy on the contralateral adrenal gland. Steroid replacement therapy was required in three patients (11%), none of whom had local recurrence. Additional data are displayed in table 1. Patient No./Surgery No. 27/36 Mean age at diagnosis, yrs (range) 27 (10-62) Right side (%) 11 (31) Indications for surgery No. (%) Pheochromocytoma-related symptoms 4 (11) Mass on CT or MRI 20 (56) Elevated catecholamines 9 (25) Concurrent abdominal surgery 1 (3) Elective surgery 2 (6) Mean size, cm (range) 2.7 (0.3-5) CONCLUSIONS Outcomes for partial adrenalectomy for pheochromocytoma in the VHL population are encouraging at a long-term follow up. Adrenal-sparing surgery can obviate the need for steroid replacement in the majority of patients. Local recurrence rates appear to be infrequent and can be managed successfully with low rates of chronic steroid dependence. Bethesda, MD© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e13 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jihane N. Benhammou More articles by this author Ronald S. Boris More articles by this author W. Marston Linehan More articles by this author Peter A. Pinto More articles by this author Gennady Bratslavsky More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W1999813198 title "30 OUTCOMES OF PARTIAL ADRENALECTOMY FOR PHEOCHROMOCYTOMA IN VHL PATIENTS AFTER AT LEAST 5 YEARS OF FOLLOW UP" @default.
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