FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999819498> ?p ?o ?g. }

• W1999819498 endingPage "2342" @default.
• W1999819498 startingPage "2338" @default.
• W1999819498 abstract "The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice." @default.
• W1999819498 created "2016-06-24" @default.
• W1999819498 creator A5001144272 @default.
• W1999819498 creator A5034184478 @default.
• W1999819498 creator A5034336406 @default.
• W1999819498 creator A5036621335 @default.
• W1999819498 creator A5050856955 @default.
• W1999819498 creator A5056358604 @default.
• W1999819498 creator A5057348818 @default.
• W1999819498 creator A5058145617 @default.
• W1999819498 creator A5065548608 @default.
• W1999819498 creator A5073986108 @default.
• W1999819498 creator A5078665796 @default.
• W1999819498 date "2012-03-01" @default.
• W1999819498 modified "2023-09-27" @default.
• W1999819498 title "Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification" @default.
• W1999819498 cites W1488493608 @default.
• W1999819498 cites W1581310431 @default.
• W1999819498 cites W1764308599 @default.
• W1999819498 cites W1844185706 @default.
• W1999819498 cites W1972297823 @default.
• W1999819498 cites W1979611175 @default.
• W1999819498 cites W2002192155 @default.
• W1999819498 cites W2010783235 @default.
• W1999819498 cites W2013377406 @default.
• W1999819498 cites W2014433643 @default.
• W1999819498 cites W2018818498 @default.
• W1999819498 cites W2038074753 @default.
• W1999819498 cites W2049108026 @default.
• W1999819498 cites W2056197807 @default.
• W1999819498 cites W2065773243 @default.
• W1999819498 cites W2067575053 @default.
• W1999819498 cites W2070850575 @default.
• W1999819498 cites W2081338286 @default.
• W1999819498 cites W2120328406 @default.
• W1999819498 cites W2123550664 @default.
• W1999819498 cites W2129740384 @default.
• W1999819498 cites W2141522397 @default.
• W1999819498 cites W2158402737 @default.
• W1999819498 cites W2312438538 @default.
• W1999819498 cites W2952384519 @default.
• W1999819498 doi "https://doi.org/10.1016/j.bmcl.2012.01.047" @default.
• W1999819498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22342142" @default.
• W1999819498 hasPublicationYear "2012" @default.
• W1999819498 type Work @default.
• W1999819498 sameAs 1999819498 @default.
• W1999819498 citedByCount "13" @default.
• W1999819498 countsByYear W19998194982012 @default.
• W1999819498 countsByYear W19998194982013 @default.
• W1999819498 countsByYear W19998194982017 @default.
• W1999819498 countsByYear W19998194982018 @default.
• W1999819498 countsByYear W19998194982019 @default.
• W1999819498 countsByYear W19998194982020 @default.
• W1999819498 countsByYear W19998194982022 @default.
• W1999819498 crossrefType "journal-article" @default.
• W1999819498 hasAuthorship W1999819498A5001144272 @default.
• W1999819498 hasAuthorship W1999819498A5034184478 @default.
• W1999819498 hasAuthorship W1999819498A5034336406 @default.
• W1999819498 hasAuthorship W1999819498A5036621335 @default.
• W1999819498 hasAuthorship W1999819498A5050856955 @default.
• W1999819498 hasAuthorship W1999819498A5056358604 @default.
• W1999819498 hasAuthorship W1999819498A5057348818 @default.
• W1999819498 hasAuthorship W1999819498A5058145617 @default.
• W1999819498 hasAuthorship W1999819498A5065548608 @default.
• W1999819498 hasAuthorship W1999819498A5073986108 @default.
• W1999819498 hasAuthorship W1999819498A5078665796 @default.
• W1999819498 hasConcept C134651460 @default.
• W1999819498 hasConcept C181199279 @default.
• W1999819498 hasConcept C185592680 @default.
• W1999819498 hasConcept C193042331 @default.
• W1999819498 hasConcept C202751555 @default.
• W1999819498 hasConcept C203014093 @default.
• W1999819498 hasConcept C2776946954 @default.
• W1999819498 hasConcept C2778327999 @default.
• W1999819498 hasConcept C55493867 @default.
• W1999819498 hasConcept C71240020 @default.
• W1999819498 hasConcept C71924100 @default.
• W1999819498 hasConcept C8891405 @default.
• W1999819498 hasConcept C96942376 @default.
• W1999819498 hasConcept C98274493 @default.
• W1999819498 hasConceptScore W1999819498C134651460 @default.
• W1999819498 hasConceptScore W1999819498C181199279 @default.
• W1999819498 hasConceptScore W1999819498C185592680 @default.
• W1999819498 hasConceptScore W1999819498C193042331 @default.
• W1999819498 hasConceptScore W1999819498C202751555 @default.
• W1999819498 hasConceptScore W1999819498C203014093 @default.
• W1999819498 hasConceptScore W1999819498C2776946954 @default.
• W1999819498 hasConceptScore W1999819498C2778327999 @default.
• W1999819498 hasConceptScore W1999819498C55493867 @default.
• W1999819498 hasConceptScore W1999819498C71240020 @default.
• W1999819498 hasConceptScore W1999819498C71924100 @default.
• W1999819498 hasConceptScore W1999819498C8891405 @default.
• W1999819498 hasConceptScore W1999819498C96942376 @default.
• W1999819498 hasConceptScore W1999819498C98274493 @default.
• W1999819498 hasIssue "6" @default.
• W1999819498 hasLocation W19998194981 @default.
• W1999819498 hasLocation W19998194982 @default.
• W1999819498 hasOpenAccess W1999819498 @default.

• next