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- W1999824908 abstract "RationaleAttempt to demonstrate nasal fluticasone propionate 200 μg daily (FP200QD) for 14 days is superior to placebo in relieving ocular symptoms.MethodsThis was a randomized, double-blind, parallel group, multicenter study comparing FP200QD with placebo in patients (n = 626, age 12 to 79 years) with seasonal allergic rhinitis. The primary endpoint was change from baseline in patient-rated reflective Total Ocular Symptoms Score (rTOSS). Secondary endpoints included change from baseline in the am and pm rTOSS, end-of-treatment assessment of response, and daily activities impact. Primary analysis was analysis of covariance (linear fixed-effects mode).ResultsFP200QD was more efficacious in ocular symptoms relief than placebo utilizing primary endpoint (difference = -0.36, p = 0.0024). It improved am and pm rTOSS vs placebo (AM: difference = -0.33, p = 0.0057; PM: difference = -0.41, p = 0.0009). More patients on FP200QD reported overall improvement at end of treatment (177 vs 146 in placebo, p = 0.0118). FP200QD significantly improved daily activities as measured by MiniRQLQ (p<0.0001) and was well tolerated.ConclusionsThe study results support that FP200QD relieves ocular symptoms in AR. RationaleAttempt to demonstrate nasal fluticasone propionate 200 μg daily (FP200QD) for 14 days is superior to placebo in relieving ocular symptoms. Attempt to demonstrate nasal fluticasone propionate 200 μg daily (FP200QD) for 14 days is superior to placebo in relieving ocular symptoms. MethodsThis was a randomized, double-blind, parallel group, multicenter study comparing FP200QD with placebo in patients (n = 626, age 12 to 79 years) with seasonal allergic rhinitis. The primary endpoint was change from baseline in patient-rated reflective Total Ocular Symptoms Score (rTOSS). Secondary endpoints included change from baseline in the am and pm rTOSS, end-of-treatment assessment of response, and daily activities impact. Primary analysis was analysis of covariance (linear fixed-effects mode). This was a randomized, double-blind, parallel group, multicenter study comparing FP200QD with placebo in patients (n = 626, age 12 to 79 years) with seasonal allergic rhinitis. The primary endpoint was change from baseline in patient-rated reflective Total Ocular Symptoms Score (rTOSS). Secondary endpoints included change from baseline in the am and pm rTOSS, end-of-treatment assessment of response, and daily activities impact. Primary analysis was analysis of covariance (linear fixed-effects mode). ResultsFP200QD was more efficacious in ocular symptoms relief than placebo utilizing primary endpoint (difference = -0.36, p = 0.0024). It improved am and pm rTOSS vs placebo (AM: difference = -0.33, p = 0.0057; PM: difference = -0.41, p = 0.0009). More patients on FP200QD reported overall improvement at end of treatment (177 vs 146 in placebo, p = 0.0118). FP200QD significantly improved daily activities as measured by MiniRQLQ (p<0.0001) and was well tolerated. FP200QD was more efficacious in ocular symptoms relief than placebo utilizing primary endpoint (difference = -0.36, p = 0.0024). It improved am and pm rTOSS vs placebo (AM: difference = -0.33, p = 0.0057; PM: difference = -0.41, p = 0.0009). More patients on FP200QD reported overall improvement at end of treatment (177 vs 146 in placebo, p = 0.0118). FP200QD significantly improved daily activities as measured by MiniRQLQ (p<0.0001) and was well tolerated. ConclusionsThe study results support that FP200QD relieves ocular symptoms in AR. The study results support that FP200QD relieves ocular symptoms in AR." @default.
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- W1999824908 date "2015-02-01" @default.
- W1999824908 modified "2023-09-27" @default.
- W1999824908 title "Efficacy of Fluticasone Propionate Nasal Spray on Ocular Symptoms Relief in Seasonal Allergic Rhinitis" @default.
- W1999824908 doi "https://doi.org/10.1016/j.jaci.2014.12.1828" @default.
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