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- W1999833705 abstract "Abstract Background: Genetic alteration of cyclin-dependent kinase inhibitors has been associated with carcinogenesis mechanisms in various organs. Objective: This study aimed to evaluate the expression and mutational analysis of Cip/Kip family cyclin-dependent kinase inhibitors (p21 CIP1/WAF1 , p27 KIP1 and p57 KIP2 ) in early glottic cancer. Methods: Expressions of Cip/Kip family and p53 were determined by quantitative reverse transcription polymerase chain reaction and densitometry. For the analysis of p21 inactivation, sequence alteration was assessed using single-strand conformational polymorphism polymerase chain reaction. Additionally, the inactivation mechanism of p27 and p57 were investigated using DNA methylation analysis. Results: Reduced expression of p27 and p57 were detected in all samples, whereas the expression of p21 was incompletely down-regulated in 6 of 11 samples. Additionally, single-strand conformational polymorphism polymerase chain reaction analysis showed the p53 mutation at exon 6. Methylation of p27 and p57 was detected by DNA methylation assay. Conclusion: Our results suggest that the Cip/Kip family may have a role as a molecular mechanism of carcinogenesis in early glottic cancer." @default.
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- W1999833705 date "2015-02-01" @default.
- W1999833705 modified "2023-09-27" @default.
- W1999833705 title "Expression and mutational analysis of Cip/Kip family in early glottic cancer" @default.
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- W1999833705 doi "https://doi.org/10.1017/s0022215114003351" @default.
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