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- W1999848469 endingPage "538" @default.
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- W1999848469 abstract "Histone deacetylase 2 (HDAC2) regulates biological processes by deacetylation of histones and non-histone proteins. HDAC2 is overexpressed in numerous cancer types, suggesting general cancer-relevant functions of HDAC2. In human tumors the TP53 gene encoding p53 is frequently mutated and wild-type p53 is often disarmed. Molecular pathways inactivating wild-type p53 often remain to be defined and understood. Remarkably, current data link HDAC2 to the regulation of the tumor suppressor p53 by deacetylation and to the maintenance of genomic stability. Here, we summarize recent findings on HDAC2 overexpression in solid and hematopoietic cancers with a focus on mechanisms connecting HDAC2 and p53 in vitro and in vivo. In addition, we present an evidence-based model that integrates molecular pathways and feedback loops by which p53 and further transcription factors govern the expression and the ubiquitin-dependent proteasomal degradation of HDAC2 and of p53 itself. Understanding the interactions between p53 and HDAC2 might aid in the development of new therapeutic approaches against cancer." @default.
- W1999848469 created "2016-06-24" @default.
- W1999848469 creator A5001180341 @default.
- W1999848469 creator A5015940174 @default.
- W1999848469 creator A5051618960 @default.
- W1999848469 creator A5090341188 @default.
- W1999848469 date "2014-12-01" @default.
- W1999848469 modified "2023-10-18" @default.
- W1999848469 title "Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis" @default.
- W1999848469 cites W1486094676 @default.
- W1999848469 cites W1547154484 @default.
- W1999848469 cites W1563624749 @default.
- W1999848469 cites W1600290788 @default.
- W1999848469 cites W1641419369 @default.
- W1999848469 cites W1648663357 @default.
- W1999848469 cites W1843609228 @default.
- W1999848469 cites W188097045 @default.
- W1999848469 cites W1964190086 @default.
- W1999848469 cites W1964392512 @default.
- W1999848469 cites W1964473274 @default.
- W1999848469 cites W1965233827 @default.
- W1999848469 cites W1966063402 @default.
- W1999848469 cites W1968417129 @default.
- W1999848469 cites W1969323007 @default.
- W1999848469 cites W1970489031 @default.
- W1999848469 cites W1971299928 @default.
- W1999848469 cites W1971947676 @default.
- W1999848469 cites W1974167857 @default.
- W1999848469 cites W1974834619 @default.
- W1999848469 cites W1976059452 @default.
- W1999848469 cites W1976153898 @default.
- W1999848469 cites W1976295398 @default.
- W1999848469 cites W1977068148 @default.
- W1999848469 cites W1977647055 @default.
- W1999848469 cites W1977665132 @default.
- W1999848469 cites W1981203939 @default.
- W1999848469 cites W1982292631 @default.
- W1999848469 cites W1982525225 @default.
- W1999848469 cites W1982619775 @default.
- W1999848469 cites W1983315005 @default.
- W1999848469 cites W1984314373 @default.
- W1999848469 cites W1984328540 @default.
- W1999848469 cites W1987012261 @default.
- W1999848469 cites W1987147220 @default.
- W1999848469 cites W1987184954 @default.
- W1999848469 cites W1987350137 @default.
- W1999848469 cites W1990316655 @default.
- W1999848469 cites W1991782223 @default.
- W1999848469 cites W1992949187 @default.
- W1999848469 cites W1993967951 @default.
- W1999848469 cites W1994746194 @default.
- W1999848469 cites W1994941668 @default.
- W1999848469 cites W1995694958 @default.
- W1999848469 cites W2002147900 @default.
- W1999848469 cites W2002426844 @default.
- W1999848469 cites W2002914764 @default.
- W1999848469 cites W2003597178 @default.
- W1999848469 cites W2007268478 @default.
- W1999848469 cites W2008054969 @default.
- W1999848469 cites W2010706742 @default.
- W1999848469 cites W2011125717 @default.
- W1999848469 cites W2013186220 @default.
- W1999848469 cites W2013588387 @default.
- W1999848469 cites W2013870404 @default.
- W1999848469 cites W2015619266 @default.
- W1999848469 cites W2016849135 @default.
- W1999848469 cites W2018682634 @default.
- W1999848469 cites W2018823286 @default.
- W1999848469 cites W2019259130 @default.
- W1999848469 cites W2019967976 @default.
- W1999848469 cites W2023237279 @default.
- W1999848469 cites W2023401613 @default.
- W1999848469 cites W2023661738 @default.
- W1999848469 cites W2024996523 @default.
- W1999848469 cites W2025220605 @default.
- W1999848469 cites W2025439169 @default.
- W1999848469 cites W2025476423 @default.
- W1999848469 cites W2025722611 @default.
- W1999848469 cites W2026969834 @default.
- W1999848469 cites W2028806642 @default.
- W1999848469 cites W2029035269 @default.
- W1999848469 cites W2029148944 @default.
- W1999848469 cites W2029484247 @default.
- W1999848469 cites W2031910372 @default.
- W1999848469 cites W2032416749 @default.
- W1999848469 cites W2032928354 @default.
- W1999848469 cites W2033421610 @default.
- W1999848469 cites W2035209422 @default.
- W1999848469 cites W2037781378 @default.
- W1999848469 cites W2038311942 @default.
- W1999848469 cites W2039139796 @default.
- W1999848469 cites W2040982566 @default.
- W1999848469 cites W2041228278 @default.
- W1999848469 cites W2042056286 @default.
- W1999848469 cites W2043467387 @default.
- W1999848469 cites W2044553988 @default.
- W1999848469 cites W2044573387 @default.
- W1999848469 cites W2046624412 @default.