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• W1999853180 abstract "Previous research on the rat corticospinal tract (CST) which develops mainly postnatally revealed that some CST axons grow transiently into the spinal gray matter and are subsequently eliminated. In the present study the question was addressed whether these fibres also form transient functional connections. Rats aged 14 and 60 days postnatally received unilateral injections of the potent glutamate agonist kainate into the cerebral motor cortex. After a survival period of 90 min. the rats were perfused and their brains and spinal cords processed for the immediate early gene c- fos by immunobistochemistry. Increased levels of c- fos as opposed to sham-operated animals was observed in several brain nuclei as well as in the cervical spinal cord. In the spinal gray one population of labelled interneurons in particular appeared to correlate well with the CST projection field. A decrease was noted in the number of c- fos positive neurons from postnatal day 14 to 60, suggesting that during development transient functional connections are formed between the CST and its target." @default.
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• W1999853180 date "1995-07-01" @default.
• W1999853180 modified "2023-09-26" @default.
• W1999853180 title "Transient functional connections between the developing corticospinal tract and cervical spinal interneurons as demonstrated by c-fos immunohistochemistry" @default.
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• W1999853180 doi "https://doi.org/10.1016/0165-3806(95)00058-l" @default.
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