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- W1999858178 abstract "The influence of the immunosuppressant cyclosporine (CsA) on the antigen-driven activation of resting cytotoxic T lymphocyte precursors (CTL-p) and on the reactivation of mixed-lymphocyte-reaction-primed CTL, is analyzed at the clonal level. Using the limiting-dilution culture approach, we show that the majority (60-90%) of clones of CTL-p with specificity for given antigens are not activated in the presence of CsA; a minority (10-40%) of CTL-p are CsA-resistant. This is so for alloantigen-reactive CTL-p and major-histocompatibility-complex-restricted CTL-p with hapten specificity. In contrast, the frequency of CTL grown out of primed mixed lymphocyte culture cells is not influenced by CsA. Although CsA does not interfere with the short-term growth of I1-2-driven activated T cells, it may influence the expression of their cytolytic potential." @default.
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- W1999858178 date "1984-11-01" @default.
- W1999858178 modified "2023-09-27" @default.
- W1999858178 title "FREQUENCY ANALYSIS OF CYCLOSPORINE-SENSITIVE CYTOTOXIC T LYMPHOCYTE PRECURSORS" @default.
- W1999858178 doi "https://doi.org/10.1097/00007890-198411000-00019" @default.
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