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- W1999858503 abstract "Epidemiological studies have suggested a negative correlation between alcohol intake and Alzheimer's disease. In vitro, ethanol negatively modulates NMDA receptor function. We hypothesized that chronic moderate alcohol intake leads to improved memory via adaptive responses in the expression of NMDA receptors and downstream signaling. We fed liquid diets containing no, moderate, or high amounts of ethanol to control and matched rats with hippocampal knock-down of the NR1 subunit. Rats with increased hippocampal NR1 expression were also generated to determine whether they had a phenotype similar to that of ethanol-fed animals. We found that moderate ethanol intake improved memory, increased NR1 expression, and changed some aspects of neurotrophin signaling. NR1 knock-down prevented ethanol's facilitatory effects, whereas hippocampal NR1 overexpression mimicked the effect of chronic low-dose ethanol intake on memory. In contrast, high-dose ethanol reduced neurogenesis, inhibited NR2B expression, and impaired visual memory. In conclusion, adaptive changes in hippocampal NMDA receptor expression may contribute to the positive effects of ethanol on cognition." @default.
- W1999858503 created "2016-06-24" @default.
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- W1999858503 date "2007-09-26" @default.
- W1999858503 modified "2023-09-23" @default.
- W1999858503 title "Paradoxical Facilitatory Effect of Low-Dose Alcohol Consumption on Memory Mediated by NMDA Receptors" @default.
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- W1999858503 cites W1488872763 @default.
- W1999858503 cites W1505521068 @default.
- W1999858503 cites W1542152284 @default.
- W1999858503 cites W1876061808 @default.
- W1999858503 cites W1968195648 @default.
- W1999858503 cites W1980750700 @default.
- W1999858503 cites W1983807711 @default.
- W1999858503 cites W1984358403 @default.
- W1999858503 cites W1985249346 @default.
- W1999858503 cites W1988182239 @default.
- W1999858503 cites W1991539323 @default.
- W1999858503 cites W1997969083 @default.
- W1999858503 cites W2004908361 @default.
- W1999858503 cites W2007296808 @default.
- W1999858503 cites W2009812062 @default.
- W1999858503 cites W2010108646 @default.
- W1999858503 cites W2014520644 @default.
- W1999858503 cites W2018861913 @default.
- W1999858503 cites W2019297438 @default.
- W1999858503 cites W2024092722 @default.
- W1999858503 cites W2028101732 @default.
- W1999858503 cites W2028241135 @default.
- W1999858503 cites W2029798914 @default.
- W1999858503 cites W2030338901 @default.
- W1999858503 cites W2035035416 @default.
- W1999858503 cites W2037858428 @default.
- W1999858503 cites W2038813826 @default.
- W1999858503 cites W2040852606 @default.
- W1999858503 cites W2041104528 @default.
- W1999858503 cites W2041291027 @default.
- W1999858503 cites W2044012386 @default.
- W1999858503 cites W2049675980 @default.
- W1999858503 cites W2053068006 @default.
- W1999858503 cites W2055605543 @default.
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- W1999858503 cites W2068253249 @default.
- W1999858503 cites W2073537077 @default.
- W1999858503 cites W2074142363 @default.
- W1999858503 cites W2077697019 @default.
- W1999858503 cites W2078035640 @default.
- W1999858503 cites W2078885313 @default.
- W1999858503 cites W2080758880 @default.
- W1999858503 cites W2085049245 @default.
- W1999858503 cites W2087338448 @default.
- W1999858503 cites W2089374585 @default.
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- W1999858503 cites W2097934194 @default.
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- W1999858503 cites W2121239869 @default.
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- W1999858503 cites W2172285943 @default.
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- W1999858503 doi "https://doi.org/10.1523/jneurosci.2789-07.2007" @default.
- W1999858503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673160" @default.
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