FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999862702> ?p ?o ?g. }

• W1999862702 endingPage "2000" @default.
• W1999862702 startingPage "1990" @default.
• W1999862702 abstract "Systemic sclerosis (SSc) is characterized by fibrosis of the skin and visceral organs, vascular dysfunction, and immunologic dysregulation. Platelet-derived growth factors (PDGFs) have been implicated in the development of fibrosis and dysregulation of vascular function. We investigated the effects of sunitinib and sorafenib, two tyrosine kinase inhibitors that interfere with PDGF signaling, in a mouse model of diffuse SSc.SSc was induced in BALB/c mice by subcutaneous injections of HOCl daily for 6 weeks. Mice were randomized to treatment with sunitinib, sorafenib, or vehicle. The levels of native and phosphorylated PDGF receptor β (PDGFRβ) and vascular endothelial growth factor receptor (VEGFR) in the skin were assessed by Western blot and immunohistochemical analyses. Skin and lung fibrosis were evaluated by histologic and biochemical methods. Autoantibodies were detected by enzyme-linked immunosorbent assay, and spleen cell populations were analyzed by flow cytometry.Phosphorylation of PDGFRβ and VEGFR was higher in fibrotic skin from HOCl-injected mice with SSc than from PBS-injected mice. Injections of HOCl induced cutaneous and lung fibrosis, increased the proliferation rate of fibroblasts in areas of fibrotic skin, increased splenic B cell and T cell counts, and increased anti-DNA topoisomerase I autoantibody levels in BALB/c mice. All of these features were reduced by sunitinib but not by sorafenib. Sunitinib significantly reduced the phosphorylation of both PDGF and VEGF receptors.Inhibition of the hyperactivated PDGF and VEGF pathways by sunitinib prevented the development of fibrosis in HOCl-induced murine SSc and may represent a new SSc treatment for testing in clinical trials." @default.
• W1999862702 created "2016-06-24" @default.
• W1999862702 creator A5034892075 @default.
• W1999862702 creator A5038293102 @default.
• W1999862702 creator A5041347383 @default.
• W1999862702 creator A5054861001 @default.
• W1999862702 creator A5056283668 @default.
• W1999862702 creator A5059590167 @default.
• W1999862702 creator A5085087884 @default.
• W1999862702 date "2012-05-25" @default.
• W1999862702 modified "2023-10-02" @default.
• W1999862702 title "Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease" @default.
• W1999862702 cites W1490888491 @default.
• W1999862702 cites W1562971597 @default.
• W1999862702 cites W1600542667 @default.
• W1999862702 cites W1920142430 @default.
• W1999862702 cites W1934827586 @default.
• W1999862702 cites W1971610159 @default.
• W1999862702 cites W1990842725 @default.
• W1999862702 cites W1993651546 @default.
• W1999862702 cites W2003248867 @default.
• W1999862702 cites W2003940493 @default.
• W1999862702 cites W2004460690 @default.
• W1999862702 cites W2010212162 @default.
• W1999862702 cites W2013568031 @default.
• W1999862702 cites W2015237288 @default.
• W1999862702 cites W2015338496 @default.
• W1999862702 cites W2020773931 @default.
• W1999862702 cites W2030619805 @default.
• W1999862702 cites W2052895143 @default.
• W1999862702 cites W2056705836 @default.
• W1999862702 cites W2057938879 @default.
• W1999862702 cites W2069417222 @default.
• W1999862702 cites W2091759543 @default.
• W1999862702 cites W2104998827 @default.
• W1999862702 cites W2118466998 @default.
• W1999862702 cites W2120233092 @default.
• W1999862702 cites W2128443991 @default.
• W1999862702 cites W2128850696 @default.
• W1999862702 cites W2131369107 @default.
• W1999862702 cites W2132084960 @default.
• W1999862702 cites W2138211373 @default.
• W1999862702 cites W2143222045 @default.
• W1999862702 cites W2152951480 @default.
• W1999862702 cites W2155214429 @default.
• W1999862702 cites W2161021883 @default.
• W1999862702 cites W2163154920 @default.
• W1999862702 cites W2164450151 @default.
• W1999862702 cites W2165763838 @default.
• W1999862702 cites W2166271687 @default.
• W1999862702 cites W2171025985 @default.
• W1999862702 cites W2171037207 @default.
• W1999862702 cites W2171131890 @default.
• W1999862702 cites W4233799263 @default.
• W1999862702 doi "https://doi.org/10.1002/art.34354" @default.
• W1999862702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22213155" @default.
• W1999862702 hasPublicationYear "2012" @default.
• W1999862702 type Work @default.
• W1999862702 sameAs 1999862702 @default.
• W1999862702 citedByCount "33" @default.
• W1999862702 countsByYear W19998627022012 @default.
• W1999862702 countsByYear W19998627022013 @default.
• W1999862702 countsByYear W19998627022014 @default.
• W1999862702 countsByYear W19998627022015 @default.
• W1999862702 countsByYear W19998627022016 @default.
• W1999862702 countsByYear W19998627022017 @default.
• W1999862702 countsByYear W19998627022018 @default.
• W1999862702 countsByYear W19998627022019 @default.
• W1999862702 countsByYear W19998627022020 @default.
• W1999862702 countsByYear W19998627022021 @default.
• W1999862702 countsByYear W19998627022022 @default.
• W1999862702 crossrefType "journal-article" @default.
• W1999862702 hasAuthorship W1999862702A5034892075 @default.
• W1999862702 hasAuthorship W1999862702A5038293102 @default.
• W1999862702 hasAuthorship W1999862702A5041347383 @default.
• W1999862702 hasAuthorship W1999862702A5054861001 @default.
• W1999862702 hasAuthorship W1999862702A5056283668 @default.
• W1999862702 hasAuthorship W1999862702A5059590167 @default.
• W1999862702 hasAuthorship W1999862702A5085087884 @default.
• W1999862702 hasBestOaLocation W19998627021 @default.
• W1999862702 hasConcept C121608353 @default.
• W1999862702 hasConcept C126322002 @default.
• W1999862702 hasConcept C134018914 @default.
• W1999862702 hasConcept C167734588 @default.
• W1999862702 hasConcept C170493617 @default.
• W1999862702 hasConcept C180361614 @default.
• W1999862702 hasConcept C203014093 @default.
• W1999862702 hasConcept C2775960820 @default.
• W1999862702 hasConcept C2777025900 @default.
• W1999862702 hasConcept C2778019345 @default.
• W1999862702 hasConcept C2778695046 @default.
• W1999862702 hasConcept C2779490328 @default.
• W1999862702 hasConcept C2780559512 @default.
• W1999862702 hasConcept C2781294074 @default.
• W1999862702 hasConcept C502942594 @default.
• W1999862702 hasConcept C71924100 @default.
• W1999862702 hasConceptScore W1999862702C121608353 @default.
• W1999862702 hasConceptScore W1999862702C126322002 @default.

• next