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• W1999881703 abstract "Aujourd'hui, la notion de faibles doses, d'une part, et la multiplicité des polluants émis en milieu industriel ou environnemental, d'autre part, compliquent l'identification des facteurs de risques néces-saire à une meilleure prevention. En outre, lors de tel es expositions, il est important de considérer l'existence potentielle de phénomènes de toxicite additive voire synergique. L'établissement de présomptions sur le rapport de causalité entre expositions multiples et pathologies requiert I'instauration d'approches à la fois complementaires et pluridisciplinaires, integrant notammert des competences en épidémiologie et en experimentation. Á l'aide de l'exemple de la co-exposition aux oxydes de fer et aux hydrocarbures polycycliques aromatiques, observée en milieu professionnel et en environnement général, cet article se propose de présenter la démarche scientifique appliquée en vue d'élucider les mécanismes physiopathologiques sous-jacents potentiellement impliqués clans la toxicite additive, voire synergique, de cette exposition concomitante. Air pollutants arising from traffic clustering and industrial production include a great number of chemical compounds that at high doses play major roles in causing many forms of respiratory disease in animal models and in some instances also in humans. However, occupational and environmental exposures are generally to low doses of complex mixtures of pollutants. Direct epidemiological evidences for adverse effects of air pollution in humans is, also, weak, and most of the available studies are limited by lack of adequate control of confounding factors and other methodological drawbacks. Moreover, it is now important to consider the potential occurrence of an addition and even a synergy between the adverse effects induced by a concurrent exposure. Perspectives and approaches to a better knowledge of the involved risk factors may include not only epidemiologic studies, to evaluate patterns of health and disease in groups of persons, but also experiments to elucidate the underlying mechanisms by which pollutants induce an additive and even a synergistic toxicity. Giving the example of the occupational andlor environmental exposure to iron oxides and polycyclic aromatic hydrocarbons, this article describes such a scientific approach." @default.
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• W1999881703 date "2003-01-01" @default.
• W1999881703 modified "2023-10-16" @default.
• W1999881703 title "Mécanismes cellulaires de la synergie d'action de polluants atmosphériques (Fe203 ET HPA) dans l'apparition du cancer broncho-pulmonaire" @default.
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• W1999881703 doi "https://doi.org/10.1016/s0338-9898(03)80471-7" @default.
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