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- W1999886226 endingPage "33115" @default.
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- W1999886226 abstract "With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed, proteopathic seeds can spread from one locale to another via cellular uptake, transport, and release. Impeding this process could represent a unified therapeutic strategy for slowing the progression of a wide range of currently intractable disorders. With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed, proteopathic seeds can spread from one locale to another via cellular uptake, transport, and release. Impeding this process could represent a unified therapeutic strategy for slowing the progression of a wide range of currently intractable disorders." @default.
- W1999886226 created "2016-06-24" @default.
- W1999886226 creator A5017808777 @default.
- W1999886226 creator A5049569922 @default.
- W1999886226 date "2012-09-01" @default.
- W1999886226 modified "2023-10-07" @default.
- W1999886226 title "Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases" @default.
- W1999886226 cites W1493986974 @default.
- W1999886226 cites W1505737561 @default.
- W1999886226 cites W1928837524 @default.
- W1999886226 cites W1963767682 @default.
- W1999886226 cites W1967069915 @default.
- W1999886226 cites W1967187624 @default.
- W1999886226 cites W1967577586 @default.
- W1999886226 cites W1968721593 @default.
- W1999886226 cites W1970033499 @default.
- W1999886226 cites W1971642895 @default.
- W1999886226 cites W1973056215 @default.
- W1999886226 cites W1977267085 @default.
- W1999886226 cites W1979807958 @default.
- W1999886226 cites W1980115442 @default.
- W1999886226 cites W1982797857 @default.
- W1999886226 cites W1989208474 @default.
- W1999886226 cites W1991462232 @default.
- W1999886226 cites W1991625887 @default.
- W1999886226 cites W1996657322 @default.
- W1999886226 cites W2004185979 @default.
- W1999886226 cites W2005755021 @default.
- W1999886226 cites W2009036046 @default.
- W1999886226 cites W2015234786 @default.
- W1999886226 cites W2016351953 @default.
- W1999886226 cites W2017062988 @default.
- W1999886226 cites W2018852249 @default.
- W1999886226 cites W2019957886 @default.
- W1999886226 cites W2023048174 @default.
- W1999886226 cites W2023529808 @default.
- W1999886226 cites W2027186506 @default.
- W1999886226 cites W2029978572 @default.
- W1999886226 cites W2031343997 @default.
- W1999886226 cites W2032355167 @default.
- W1999886226 cites W2032559950 @default.
- W1999886226 cites W2035339855 @default.
- W1999886226 cites W2036599501 @default.
- W1999886226 cites W2039706105 @default.
- W1999886226 cites W2044407202 @default.
- W1999886226 cites W2046885195 @default.
- W1999886226 cites W2050647292 @default.
- W1999886226 cites W2050686349 @default.
- W1999886226 cites W2050786534 @default.
- W1999886226 cites W2053082937 @default.
- W1999886226 cites W2055346376 @default.
- W1999886226 cites W2058905710 @default.
- W1999886226 cites W2063198655 @default.
- W1999886226 cites W2064367582 @default.
- W1999886226 cites W2067682626 @default.
- W1999886226 cites W2071967414 @default.
- W1999886226 cites W2072545392 @default.
- W1999886226 cites W2073449985 @default.
- W1999886226 cites W2075793841 @default.
- W1999886226 cites W2076159058 @default.
- W1999886226 cites W2076535829 @default.
- W1999886226 cites W2076844276 @default.
- W1999886226 cites W2080816290 @default.
- W1999886226 cites W2084121214 @default.
- W1999886226 cites W2084469782 @default.
- W1999886226 cites W2084993091 @default.
- W1999886226 cites W2085703547 @default.
- W1999886226 cites W2088079659 @default.
- W1999886226 cites W2089215677 @default.
- W1999886226 cites W2089691915 @default.
- W1999886226 cites W2095963715 @default.
- W1999886226 cites W2096347759 @default.
- W1999886226 cites W2097891553 @default.
- W1999886226 cites W2098022922 @default.
- W1999886226 cites W2099340107 @default.
- W1999886226 cites W2100111801 @default.
- W1999886226 cites W2100421640 @default.
- W1999886226 cites W2105047187 @default.
- W1999886226 cites W2113281193 @default.
- W1999886226 cites W2121396616 @default.
- W1999886226 cites W2126169120 @default.
- W1999886226 cites W2128341112 @default.
- W1999886226 cites W2131222480 @default.
- W1999886226 cites W2132121416 @default.
- W1999886226 cites W2133007412 @default.
- W1999886226 cites W2138390885 @default.
- W1999886226 cites W2141346064 @default.
- W1999886226 cites W2141583055 @default.
- W1999886226 cites W2145106678 @default.
- W1999886226 cites W2145859760 @default.
- W1999886226 cites W2152217159 @default.
- W1999886226 cites W2152340197 @default.
- W1999886226 cites W2154584808 @default.
- W1999886226 cites W2157557701 @default.
- W1999886226 cites W2157617823 @default.
- W1999886226 cites W2162698318 @default.
- W1999886226 cites W2171495114 @default.
- W1999886226 cites W2324660492 @default.