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• W1999893419 abstract "Early symptomatic treatment of acute unilateral vestibulopathy is thought to impede the course of ensuing central vestibular compensation (VC). Despite the great clinical importance of this hypothesis there is no experimental evidence of its validity. The present study addressed this question by investigating the direct effect of 4-aminopyridine (4-AP) on ocular motor and postural symptoms in acute unilateral vestibulopathy as well as its long-term consequences for VC in a rat model of chemical unilateral labyrinthectomy (UL). After UL, one group of Sprague–Dawley rats was treated with 4-AP p.o. (1 mg/kg/day), another with 0.9% NaCl solution p.o. for 3 days. Behavioural testing for symptoms of vestibular tone imbalance was done 1 day before and 1, 2, 3, 5, 7, 9, 15, 21, and 30 days after UL. In addition, sequential whole-brain [18F]-FDG-μPET was performed before and 1, 3, 7, 15, and 30 days after UL to examine and visualize 4-AP-induced modulation of VC. Administration of 4-AP on days 1–3 significantly improved postural imbalance 2 h after administration compared to that in controls. This effect was only transient. Remarkably, the 4-AP group had a prolonged and impaired course of postural compensation compared to that of controls. The μPET revealed a significant increase of regional cerebral glucose metabolism (rCGM) in the vestibulocerebellum 2 h after administration of 4-AP. However, the 4-AP group exhibited a persistent asymmetry of rCGM after day 3 in the vestibular nuclei and posterolateral thalami. In conclusion, this study confirms the hypothesis that early pharmacological abatement of vestibular symptoms impedes VC." @default.
• W1999893419 created "2016-06-24" @default.
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• W1999893419 date "2014-11-01" @default.
• W1999893419 modified "2023-10-09" @default.
• W1999893419 title "The mixed blessing of treating symptoms in acute vestibular failure — Evidence from a 4-aminopyridine experiment" @default.
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• W1999893419 doi "https://doi.org/10.1016/j.expneurol.2014.08.013" @default.
• W1999893419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25157903" @default.
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