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- W199990832 abstract "SummaryMolecular targets represent the cumulative and ongoing dissection of the dynamic process of malignant progression and the hope for improved survival for the future. Identification of a precursor lesion, molecular, or physiologic makes molecular dissection and therapeutic targeting more direct. Thus, clinical and laboratory investigators are using the role of common molecular targets, such as those underlying angiogenesis or general proliferation, survival, and invasion from which to design therapeutic strategies. New therapies directed at molecular targets are being actively evaluated in many malignancies, including ovarian and endometrial cancers. Increasing knowledge about the molecular basis of disease has allowed dissection of the events that underlie tumor development and progression as well as the supportive changes that occur in the microenvironment of the tumor and its metastases. Taking the next step to validate the regulation of the targets in the patient, in the tumor, and in the local microenvironment may disprove the specific target hypothesis but will enrich our understanding of the next steps. Early detection has changed the face of endometrial cancer, and molecular targeting will further improve that landscape. This chapter details the major molecular pathways that are known to be important in ovarian and endometrial cancer and their potential as therapeutic targets." @default.
- W199990832 created "2016-06-24" @default.
- W199990832 creator A5005621340 @default.
- W199990832 creator A5034364793 @default.
- W199990832 creator A5060219345 @default.
- W199990832 date "2007-12-25" @default.
- W199990832 modified "2023-09-25" @default.
- W199990832 title "Molecular Targets in Ovarian Cancer and Endometrial Cancer" @default.
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