Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999908526> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W1999908526 endingPage "2855" @default.
- W1999908526 startingPage "2850" @default.
- W1999908526 abstract "Interaction of immunoliposomes composed of dioleoylphosphatidylethanolamine (DOPE) (80%), dioleoylphosphatidic acid (DOPA) (20%), and a small amount of specific antibody with Herpes Simplex virus (HSV) were studied by detecting the immune-dependent lysis of liposomes. DOPA was used as the principal stabilizer of the immunoliposomes. Antibodies conjugated with N-glutarylphosphatidylethanolamine or oxidized GM1 served as the target-specific ligands of immunoliposomes. These immunoliposomes (d = 160-180 nm) were stable for at least one month when stored at 4 degrees C. However, they undergo a rapid aggregation and lysis reaction in the presence of a membrane-bound target such as intact HSV virions. We have also employed epitope peptide-containing liposomes (target liposomes) to mimic the virus and showed that the immunoliposomes could be aggregated and lysed by the target liposomes in an antigen-dependent manner. Immunoliposome lysis could be accelerated by increasing the incubation temperature to 60-70 degrees C. No immunoliposome lysis was observed if the target liposomes were absent, indicating the prolonged stability of the immunoliposomes. Liposome lysis was always accompanied by liposome aggregation. However, the aggregation-induced liposome destabilization is unique to the HII phase-forming lipids such as DOPE. DOPC-containing immunoliposomes did not lyse despite the fact that massive liposome aggregation had taken place." @default.
- W1999908526 created "2016-06-24" @default.
- W1999908526 creator A5018222046 @default.
- W1999908526 creator A5042358002 @default.
- W1999908526 date "1992-03-01" @default.
- W1999908526 modified "2023-09-26" @default.
- W1999908526 title "Stable target-sensitive immunoliposomes" @default.
- W1999908526 doi "https://doi.org/10.1021/bi00126a002" @default.
- W1999908526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1372514" @default.
- W1999908526 hasPublicationYear "1992" @default.
- W1999908526 type Work @default.
- W1999908526 sameAs 1999908526 @default.
- W1999908526 citedByCount "37" @default.
- W1999908526 countsByYear W19999085262013 @default.
- W1999908526 countsByYear W19999085262015 @default.
- W1999908526 countsByYear W19999085262018 @default.
- W1999908526 crossrefType "journal-article" @default.
- W1999908526 hasAuthorship W1999908526A5018222046 @default.
- W1999908526 hasAuthorship W1999908526A5042358002 @default.
- W1999908526 hasConcept C12554922 @default.
- W1999908526 hasConcept C130316041 @default.
- W1999908526 hasConcept C13245373 @default.
- W1999908526 hasConcept C178790620 @default.
- W1999908526 hasConcept C185154212 @default.
- W1999908526 hasConcept C185592680 @default.
- W1999908526 hasConcept C2779820397 @default.
- W1999908526 hasConcept C41625074 @default.
- W1999908526 hasConcept C55493867 @default.
- W1999908526 hasConcept C57409179 @default.
- W1999908526 hasConcept C86803240 @default.
- W1999908526 hasConceptScore W1999908526C12554922 @default.
- W1999908526 hasConceptScore W1999908526C130316041 @default.
- W1999908526 hasConceptScore W1999908526C13245373 @default.
- W1999908526 hasConceptScore W1999908526C178790620 @default.
- W1999908526 hasConceptScore W1999908526C185154212 @default.
- W1999908526 hasConceptScore W1999908526C185592680 @default.
- W1999908526 hasConceptScore W1999908526C2779820397 @default.
- W1999908526 hasConceptScore W1999908526C41625074 @default.
- W1999908526 hasConceptScore W1999908526C55493867 @default.
- W1999908526 hasConceptScore W1999908526C57409179 @default.
- W1999908526 hasConceptScore W1999908526C86803240 @default.
- W1999908526 hasIssue "11" @default.
- W1999908526 hasLocation W19999085261 @default.
- W1999908526 hasLocation W19999085262 @default.
- W1999908526 hasOpenAccess W1999908526 @default.
- W1999908526 hasPrimaryLocation W19999085261 @default.
- W1999908526 hasRelatedWork W101901099 @default.
- W1999908526 hasRelatedWork W161316152 @default.
- W1999908526 hasRelatedWork W2004349481 @default.
- W1999908526 hasRelatedWork W2045308798 @default.
- W1999908526 hasRelatedWork W2061604571 @default.
- W1999908526 hasRelatedWork W2089532729 @default.
- W1999908526 hasRelatedWork W2169823182 @default.
- W1999908526 hasRelatedWork W2898391111 @default.
- W1999908526 hasRelatedWork W4315702974 @default.
- W1999908526 hasRelatedWork W4384159285 @default.
- W1999908526 hasVolume "31" @default.
- W1999908526 isParatext "false" @default.
- W1999908526 isRetracted "false" @default.
- W1999908526 magId "1999908526" @default.
- W1999908526 workType "article" @default.