FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999931005> ?p ?o ?g. }

• W1999931005 endingPage "1671" @default.
• W1999931005 startingPage "1657" @default.
• W1999931005 abstract "The products encoded by the E2 open reading frame of the papillomaviruses are DNA-binding transcription factors involved in the positive or negative regulation of multiple viral promoters. To further understand the mechanisms by which the same transcription factor may act differentially, the full-length BPV-1 E2 protein was expressed and purified from yeast and assayed in vitro for its capacity to modulate transcription. E2 stimulated transcription of the HSV thymidine kinase (TK) promoter when E2-binding sites were positioned in an enhancer configuration approximately 100 bp upstream of the promoter start site. In contrast, the same full-length E2 protein repressed transcription of the HPV-18 E6/E7 P105 promoter. This repression was mediated through binding to the E2 DNA-binding site immediately upstream of the P105 promoter TATA box and could be abrogated by preincubation of the HPV-18 P105 promoter template with the nuclear extract allowing the formation of the preinitiation complex. In vitro DNA-binding experiments with purified E2 and TFIID showed that binding of E2 to its DNA target placed at different positions with respect to the TATA box differentially affects binding of TFIID to its cognate site. In these respects, E2 is similar to the bacteriophage lambda repressor, which can act either as a repressor or an activator of transcription depending on the position of its binding sites relative to the promoter sequences." @default.
• W1999931005 created "2016-06-24" @default.
• W1999931005 creator A5015582793 @default.
• W1999931005 creator A5043603982 @default.
• W1999931005 creator A5047800178 @default.
• W1999931005 creator A5078318401 @default.
• W1999931005 creator A5088065482 @default.
• W1999931005 creator A5089706444 @default.
• W1999931005 date "1991-09-01" @default.
• W1999931005 modified "2023-09-25" @default.
• W1999931005 title "The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex." @default.
• W1999931005 cites W146101514 @default.
• W1999931005 cites W1477362861 @default.
• W1999931005 cites W1512237949 @default.
• W1999931005 cites W1520282948 @default.
• W1999931005 cites W1526247840 @default.
• W1999931005 cites W1527727842 @default.
• W1999931005 cites W1531193576 @default.
• W1999931005 cites W1539426772 @default.
• W1999931005 cites W1570914391 @default.
• W1999931005 cites W1696730408 @default.
• W1999931005 cites W1767781328 @default.
• W1999931005 cites W1830126998 @default.
• W1999931005 cites W1832523854 @default.
• W1999931005 cites W1919570531 @default.
• W1999931005 cites W1936008327 @default.
• W1999931005 cites W1964129540 @default.
• W1999931005 cites W1965258786 @default.
• W1999931005 cites W1966124176 @default.
• W1999931005 cites W1967767330 @default.
• W1999931005 cites W1967960141 @default.
• W1999931005 cites W1970224035 @default.
• W1999931005 cites W1972042181 @default.
• W1999931005 cites W1975862584 @default.
• W1999931005 cites W1975987535 @default.
• W1999931005 cites W1977393774 @default.
• W1999931005 cites W1977694232 @default.
• W1999931005 cites W1981104024 @default.
• W1999931005 cites W1987811801 @default.
• W1999931005 cites W1999745373 @default.
• W1999931005 cites W2005145783 @default.
• W1999931005 cites W2018951912 @default.
• W1999931005 cites W2021059161 @default.
• W1999931005 cites W2026548183 @default.
• W1999931005 cites W2038964449 @default.
• W1999931005 cites W2044865169 @default.
• W1999931005 cites W2052357638 @default.
• W1999931005 cites W2055982132 @default.
• W1999931005 cites W2065867057 @default.
• W1999931005 cites W2067009740 @default.
• W1999931005 cites W2068577315 @default.
• W1999931005 cites W2069536687 @default.
• W1999931005 cites W2081643570 @default.
• W1999931005 cites W2088839009 @default.
• W1999931005 cites W2091160336 @default.
• W1999931005 cites W2091423718 @default.
• W1999931005 cites W2170236318 @default.
• W1999931005 cites W2170499910 @default.
• W1999931005 cites W314887280 @default.
• W1999931005 cites W911767610 @default.
• W1999931005 doi "https://doi.org/10.1101/gad.5.9.1657" @default.
• W1999931005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1653173" @default.
• W1999931005 hasPublicationYear "1991" @default.
• W1999931005 type Work @default.
• W1999931005 sameAs 1999931005 @default.
• W1999931005 citedByCount "150" @default.
• W1999931005 countsByYear W19999310052012 @default.
• W1999931005 countsByYear W19999310052013 @default.
• W1999931005 countsByYear W19999310052014 @default.
• W1999931005 countsByYear W19999310052015 @default.
• W1999931005 countsByYear W19999310052016 @default.
• W1999931005 countsByYear W19999310052018 @default.
• W1999931005 countsByYear W19999310052019 @default.
• W1999931005 countsByYear W19999310052020 @default.
• W1999931005 countsByYear W19999310052022 @default.
• W1999931005 crossrefType "journal-article" @default.
• W1999931005 hasAuthorship W1999931005A5015582793 @default.
• W1999931005 hasAuthorship W1999931005A5043603982 @default.
• W1999931005 hasAuthorship W1999931005A5047800178 @default.
• W1999931005 hasAuthorship W1999931005A5078318401 @default.
• W1999931005 hasAuthorship W1999931005A5088065482 @default.
• W1999931005 hasAuthorship W1999931005A5089706444 @default.
• W1999931005 hasBestOaLocation W19999310051 @default.
• W1999931005 hasConcept C101762097 @default.
• W1999931005 hasConcept C102622118 @default.
• W1999931005 hasConcept C104317684 @default.
• W1999931005 hasConcept C105208137 @default.
• W1999931005 hasConcept C107824862 @default.
• W1999931005 hasConcept C111936080 @default.
• W1999931005 hasConcept C132376346 @default.
• W1999931005 hasConcept C138885662 @default.
• W1999931005 hasConcept C144825837 @default.
• W1999931005 hasConcept C150194340 @default.
• W1999931005 hasConcept C153911025 @default.
• W1999931005 hasConcept C158448853 @default.
• W1999931005 hasConcept C172768829 @default.
• W1999931005 hasConcept C179716448 @default.
• W1999931005 hasConcept C179926584 @default.

• next