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• W1999935463 abstract "Improved non-invasive and invasive methods of blood pressure measurements in the newborn infant led to an increasing recognition of neonatal hypertension as a not uncommon occurrence in the neonatal period. Arterial blood pressure in the newborn is a function of gestational and postnatal ages. Systolic and diastolic blood pressures in term newborns greater than 90 mmHg and 60 mmHg, respectively, and values greater than 80 mmHg and 50 mmHg in premature newborns have been arbitrarily set as hypertension in this population. Renovascular causes may be responsible for up to 80% of neonatal hypertension followed by coarctation of the aorta and drugs (e.g. steroids). The pharmacological management of neonatal hypertension is empirical and remains a matter of debate. Drugs used in the management include the acetylcholine esterase (ACE) inhibitors (Enalapril, captopril), beta blockers (Labetolol, Atenolol), vasodilators (Hydralazine, Diazoxide), calcium channel blockers (Nifedipine) and diuretics (Furosemide, ethacrynic acid, thiazides). Definitive management should be directed to the aetiology of the hypertension. Systematic studies on the safe and effective drug management of neonatal hypertension should be a part of future research. Improved non-invasive and invasive methods of blood pressure measurements in the newborn infant led to an increasing recognition of neonatal hypertension as a not uncommon occurrence in the neonatal period. Arterial blood pressure in the newborn is a function of gestational and postnatal ages. Systolic and diastolic blood pressures in term newborns greater than 90 mmHg and 60 mmHg, respectively, and values greater than 80 mmHg and 50 mmHg in premature newborns have been arbitrarily set as hypertension in this population. Renovascular causes may be responsible for up to 80% of neonatal hypertension followed by coarctation of the aorta and drugs (e.g. steroids). The pharmacological management of neonatal hypertension is empirical and remains a matter of debate. Drugs used in the management include the acetylcholine esterase (ACE) inhibitors (Enalapril, captopril), beta blockers (Labetolol, Atenolol), vasodilators (Hydralazine, Diazoxide), calcium channel blockers (Nifedipine) and diuretics (Furosemide, ethacrynic acid, thiazides). Definitive management should be directed to the aetiology of the hypertension. Systematic studies on the safe and effective drug management of neonatal hypertension should be a part of future research. ErratumSeminars in NeonatologyVol. 3Issue 4Preview Full-Text PDF" @default.
• W1999935463 created "2016-06-24" @default.
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• W1999935463 date "1998-05-01" @default.
• W1999935463 modified "2023-09-26" @default.
• W1999935463 title "Pharmacological approach to the management of neonatal hypertension" @default.
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• W1999935463 doi "https://doi.org/10.1016/s1084-2756(98)80033-x" @default.
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