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- W1999938511 abstract "To compare changes on grafted internal mammary artery (IMA) flow after cardiopulmonary bypass in response to the administration of milrinone or epinephrine.Prospective and randomized.University-affiliated hospital.Twenty consenting, adult patients undergoing CABG.Patients were randomized to receive either milrinone, 50 microg/kg, or epinephrine, 0.03 microg/kg/min, immediately after cardiopulmonary bypass. IMA flow was measured with a laser Doppler flow probe before and after the administration of either drug.Baseline grafted IMA flow was similar for both groups (milrinone, 38+/-14 mL/min; epinephrine, 33+/-10 mL/min). In patients who received milrinone, flow increased by 24% to 50+/-17 mL/min, p<0.05; whereas with epinephrine, it remained essentially unchanged (33+/-10 v. 31+/-11 mL/min).This study confirms that the vasodilatory effect of milrinone on the IMA is also present after its anastomosis, whereas low-dose epinephrine exhibits neither beneficial nor adverse effects. It is suggested that in the absence of excessive vasodilation, milrinone should be considered as a first-line inotrope after coronary artery bypass graft surgery, to achieve an increase in contractility and IMA artery flow." @default.
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- W1999938511 date "2000-02-01" @default.
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- W1999938511 title "Effects of milrinone versus epinephrine on grafted internal mammary artery flow after cardiopulmonary bypass" @default.
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- W1999938511 doi "https://doi.org/10.1016/s1053-0770(00)90047-8" @default.
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