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• W1999939968 abstract "The abortifacient activity of prostaglandin F 2α was investigated by placing one or two 50 mg tablets of prostaglandin F 2α in THAM salt into the vagina of nine women less than 4 weeks pregnant at intervals of 2 to 4 hours for a 24 hour period. Serum levels of HCG, estradiol (E 2 ), progesterone and 17α-hydroxyprogesterone were measured by radioimmunoassay prior to starting therapy and at frequent intervals thereafter for 48 hours. All but two patients had significant side-effects, mainly diarrhea and vomiting, indicating that systemic absorption took place. Although bleeding was induced in 8 of 9 women, only 3 had complete abortions. A D&C was performed on all patients 48 hours after starting therapy. A significant fall in HCG levels was noted only in the patients who aborted. Only 3 of the 9 women had significant changes in steroid levels. A fall in progesterone and 17α-hydroxyprogesterone occurred in the 3 women who aborted and took place following the fall in HCG. Estradiol levels remained in the same range in all subjects. These findings indicate that prostaglandin F 2α when administered in this vehicle and this dosage is relatively ineffective as an abortifacient. When effective, its action would appear to be due to contractions of uterine muscle and not secondarily to luteolysis." @default.
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• W1999939968 date "1972-12-01" @default.
• W1999939968 modified "2023-09-24" @default.
• W1999939968 title "Termination of early gestation with vaginal prostaglandin F2α tablets" @default.
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• W1999939968 doi "https://doi.org/10.1016/s0090-6980(72)80032-7" @default.
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