FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999942080> ?p ?o ?g. }

• W1999942080 endingPage "4533" @default.
• W1999942080 startingPage "4533" @default.
• W1999942080 abstract "Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles Ugutz Unzueta,1–3 María Virtudes Céspedes,3,4 Neus Ferrer-Miralles,1–3 Isolda Casanova,3,4 Juan Cedano,5 José Luis Corchero,1–3 Joan Domingo-Espín,1–3 Antonio Villaverde,1–3 Ramón Mangues,3,4 Esther Vázquez1–31Institut de Biotecnologia i de Biomedicina, 2Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 3CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona, 4Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 5Laboratory of Immunology, Regional Norte, Universidad de la Republica, Salto, UruguayBackground: Cell-targeting peptides or proteins are appealing tools in nanomedicine and innovative medicines because they increase the local drug concentration and reduce potential side effects. CXC chemokine receptor 4 (CXCR4) is a cell surface marker associated with several severe human pathologies, including colorectal cancer, for which intracellular targeting agents are currently missing.Results: Four different peptides that bind CXCR4 were tested for their ability to internalize a green fluorescent protein-based reporter nanoparticle into CXCR4+ cells. Among them, only the 18 mer peptide T22, an engineered segment derivative of polyphemusin II from the horseshoe crab, efficiently penetrated target cells via a rapid, receptor-specific endosomal route. This resulted in accumulation of the reporter nanoparticle in a fully fluorescent and stable form in the perinuclear region of the target cells, without toxicity either in cell culture or in an in vivo model of metastatic colorectal cancer.Conclusion: Given the urgent demand for targeting agents in the research, diagnosis, and treatment of CXCR4-linked diseases, including colorectal cancer and human immunodeficiency virus infection, T22 appears to be a promising tag for the intracellular delivery of protein drugs, nanoparticles, and imaging agents.Keywords: peptide tag, CXCR4, intracellular targeting, self-assembling, nanoparticles, colorectal cancer" @default.
• W1999942080 created "2016-06-24" @default.
• W1999942080 creator A5023851438 @default.
• W1999942080 creator A5029397880 @default.
• W1999942080 creator A5029892045 @default.
• W1999942080 creator A5041180389 @default.
• W1999942080 creator A5041996335 @default.
• W1999942080 creator A5042249122 @default.
• W1999942080 creator A5045814102 @default.
• W1999942080 creator A5057224975 @default.
• W1999942080 creator A5069727711 @default.
• W1999942080 creator A5090326207 @default.
• W1999942080 date "2012-08-01" @default.
• W1999942080 modified "2023-10-14" @default.
• W1999942080 title "Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles" @default.
• W1999942080 cites W1809740262 @default.
• W1999942080 cites W1965063429 @default.
• W1999942080 cites W1969864388 @default.
• W1999942080 cites W1974328448 @default.
• W1999942080 cites W1979381430 @default.
• W1999942080 cites W1980799257 @default.
• W1999942080 cites W1986299453 @default.
• W1999942080 cites W2005975965 @default.
• W1999942080 cites W2008576706 @default.
• W1999942080 cites W2012875979 @default.
• W1999942080 cites W2015212957 @default.
• W1999942080 cites W2021590436 @default.
• W1999942080 cites W2022590560 @default.
• W1999942080 cites W2037132702 @default.
• W1999942080 cites W2055862301 @default.
• W1999942080 cites W2060703883 @default.
• W1999942080 cites W2065383116 @default.
• W1999942080 cites W2078442500 @default.
• W1999942080 cites W2079643454 @default.
• W1999942080 cites W2080275318 @default.
• W1999942080 cites W2097372908 @default.
• W1999942080 cites W2099598197 @default.
• W1999942080 cites W2102817082 @default.
• W1999942080 cites W2103178838 @default.
• W1999942080 cites W2105009451 @default.
• W1999942080 cites W2105292533 @default.
• W1999942080 cites W2106337930 @default.
• W1999942080 cites W2108075741 @default.
• W1999942080 cites W2108538162 @default.
• W1999942080 cites W2109678171 @default.
• W1999942080 cites W2121548063 @default.
• W1999942080 cites W2128635872 @default.
• W1999942080 cites W2133212644 @default.
• W1999942080 cites W2134204741 @default.
• W1999942080 cites W2136032819 @default.
• W1999942080 cites W2143481612 @default.
• W1999942080 cites W2149698088 @default.
• W1999942080 cites W2156701124 @default.
• W1999942080 cites W2158294445 @default.
• W1999942080 cites W2163367650 @default.
• W1999942080 cites W2168989044 @default.
• W1999942080 cites W2171174508 @default.
• W1999942080 cites W2322989230 @default.
• W1999942080 cites W2416957871 @default.
• W1999942080 cites W2950742636 @default.
• W1999942080 cites W50373758 @default.
• W1999942080 cites W2005038265 @default.
• W1999942080 doi "https://doi.org/10.2147/ijn.s34450" @default.
• W1999942080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3423154" @default.
• W1999942080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22923991" @default.
• W1999942080 hasPublicationYear "2012" @default.
• W1999942080 type Work @default.
• W1999942080 sameAs 1999942080 @default.
• W1999942080 citedByCount "35" @default.
• W1999942080 countsByYear W19999420802013 @default.
• W1999942080 countsByYear W19999420802015 @default.
• W1999942080 countsByYear W19999420802016 @default.
• W1999942080 countsByYear W19999420802018 @default.
• W1999942080 countsByYear W19999420802019 @default.
• W1999942080 countsByYear W19999420802020 @default.
• W1999942080 countsByYear W19999420802021 @default.
• W1999942080 countsByYear W19999420802022 @default.
• W1999942080 countsByYear W19999420802023 @default.
• W1999942080 crossrefType "journal-article" @default.
• W1999942080 hasAuthorship W1999942080A5023851438 @default.
• W1999942080 hasAuthorship W1999942080A5029397880 @default.
• W1999942080 hasAuthorship W1999942080A5029892045 @default.
• W1999942080 hasAuthorship W1999942080A5041180389 @default.
• W1999942080 hasAuthorship W1999942080A5041996335 @default.
• W1999942080 hasAuthorship W1999942080A5042249122 @default.
• W1999942080 hasAuthorship W1999942080A5045814102 @default.
• W1999942080 hasAuthorship W1999942080A5057224975 @default.
• W1999942080 hasAuthorship W1999942080A5069727711 @default.
• W1999942080 hasAuthorship W1999942080A5090326207 @default.
• W1999942080 hasBestOaLocation W19999420801 @default.
• W1999942080 hasConcept C102747710 @default.
• W1999942080 hasConcept C129470790 @default.
• W1999942080 hasConcept C13373296 @default.
• W1999942080 hasConcept C15083742 @default.
• W1999942080 hasConcept C153911025 @default.
• W1999942080 hasConcept C155672457 @default.
• W1999942080 hasConcept C170493617 @default.
• W1999942080 hasConcept C171250308 @default.

• next