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• W1999951520 abstract "CD4+ regulatory T cells (Tregs) play an important role in maintaining immune tolerance by suppressing pathologic immune responses. The generation of large numbers of antigen-specific Tregs ex vivo is critical for the development of clinical immunotherapy based on the adoptive transfer of Tregs. Both CD40-activated B cells (CD40-B) and immature dendritic cells (imDCs) have been used as professional antigen-presenting cells (APCs) to generate antigen-specific Tregs. However, the efficiencies of CD40-B and imDCs to generate CD4+ Tregs have not been compared directly and the mechanism driving the generation of these Tregs remains largely unknown. In this study, we found that CD40-B exhibited mature phenotypes and were more able to induce and expand CD4highCD25+ Tregs than imDCs. Moreover, Tregs induced by CD40-B had greater suppressive capacity than those induced by imDCs. The generation of CD4highCD25+ Tregs by CD40-B and imDCs is cell–cell contact dependent and partially relies on the expression of human leukocyte antigen (HLA)-DR and CD80/86. Differences in CD4highCD25+ Treg generation efficiency were largely explained by the production of endogenous IL-2 by CD40-B. Our results suggest that CD40-B is better able to generate large numbers of antigen-specific Tregs than imDCs. Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases." @default.
• W1999951520 created "2016-06-24" @default.
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• W1999951520 creator A5077617287 @default.
• W1999951520 date "2010-01-01" @default.
• W1999951520 modified "2023-10-01" @default.
• W1999951520 title "CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4+ regulatory T cells" @default.
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• W1999951520 doi "https://doi.org/10.1038/cmi.2009.103" @default.
• W1999951520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003254" @default.
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