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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999952052> ?p ?o ?g. }

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• W1999952052 abstract "The objective was to assess outcomes of IFNgamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNgamma and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNgamma-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNgamma suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNgamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion." @default.
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• W1999952052 date "2010-01-01" @default.
• W1999952052 modified "2023-09-27" @default.
• W1999952052 title "IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan" @default.
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• W1999952052 doi "https://doi.org/10.1016/j.cellimm.2010.02.013" @default.
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