Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999952230> ?p ?o ?g. }
- W1999952230 endingPage "1101" @default.
- W1999952230 startingPage "1096" @default.
- W1999952230 abstract "Nitrosyl hydride, HNO, also commonly termed nitroxyl, is a transient species that has been implicated in the biological activity of nitric oxide, NO. Herein, we report the first generation of a stable HNO-metal complex by direct trapping of free HNO. Deoxymyoglobin (Mb-Fe(II)) rapidly reacts with HNO produced from the decomposition of methylsulfonylhydroxylamine (MSHA) or Angeli's salt (AS) in aqueous solutions from pH 7 to pH 10, forming an adduct, Mb-HNO. The unique 1H NMR signal of the Fe-bound HNO at 14.8 ppm allows definitive proof of its formation. The generation of Mb-HNO and quantification of various myoglobin byproducts were accomplished by correlation of 1H NMR, UV-vis, and EPR spectroscopies. Typically, the maximum Mb-HNO yield obtained is 60-80%; competitive side reactions with byproducts as well as the further reactivity of the Mb-HNO decrease the overall yield. At pH 10, the observed rate of Mb-HNO generation by trapping HNO from MSHA is close to that for MSHA decomposition; kinetic simulations give a lower limit to the bimolecular rate of trapping as 1.4 x 10(4) M(-1) s(-1). The binding of HNO to deoxymyoglobin is rapid and essentially irreversible, which suggests that the biological activity of nitroxyl may be mediated by its reactivity with ferrous heme proteins such as myoglobin and hemoglobin." @default.
- W1999952230 created "2016-06-24" @default.
- W1999952230 creator A5045418636 @default.
- W1999952230 creator A5049835071 @default.
- W1999952230 creator A5074245378 @default.
- W1999952230 creator A5081040498 @default.
- W1999952230 date "2004-01-13" @default.
- W1999952230 modified "2023-10-11" @default.
- W1999952230 title "Efficient Trapping of HNO by Deoxymyoglobin" @default.
- W1999952230 cites W135372508 @default.
- W1999952230 cites W1491738624 @default.
- W1999952230 cites W1525159534 @default.
- W1999952230 cites W1529539732 @default.
- W1999952230 cites W1572341324 @default.
- W1999952230 cites W1589586351 @default.
- W1999952230 cites W1874097147 @default.
- W1999952230 cites W1964058023 @default.
- W1999952230 cites W1967253107 @default.
- W1999952230 cites W1968033597 @default.
- W1999952230 cites W1973434126 @default.
- W1999952230 cites W1976645176 @default.
- W1999952230 cites W1981725248 @default.
- W1999952230 cites W1982238657 @default.
- W1999952230 cites W1993020016 @default.
- W1999952230 cites W1999441551 @default.
- W1999952230 cites W2000943794 @default.
- W1999952230 cites W2005540859 @default.
- W1999952230 cites W2015677976 @default.
- W1999952230 cites W2019814232 @default.
- W1999952230 cites W2025545694 @default.
- W1999952230 cites W2026155860 @default.
- W1999952230 cites W2034592170 @default.
- W1999952230 cites W2036189255 @default.
- W1999952230 cites W2036282005 @default.
- W1999952230 cites W2036993395 @default.
- W1999952230 cites W2045031157 @default.
- W1999952230 cites W2045429393 @default.
- W1999952230 cites W2050264954 @default.
- W1999952230 cites W2063117863 @default.
- W1999952230 cites W2065494054 @default.
- W1999952230 cites W2067821736 @default.
- W1999952230 cites W2067990742 @default.
- W1999952230 cites W2070813931 @default.
- W1999952230 cites W2077073945 @default.
- W1999952230 cites W2085930582 @default.
- W1999952230 cites W2086043766 @default.
- W1999952230 cites W2092352316 @default.
- W1999952230 cites W23222670 @default.
- W1999952230 cites W2951603782 @default.
- W1999952230 cites W2952715757 @default.
- W1999952230 cites W3004635614 @default.
- W1999952230 cites W4233707241 @default.
- W1999952230 cites W94450722 @default.
- W1999952230 doi "https://doi.org/10.1021/ja0376184" @default.
- W1999952230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14746478" @default.
- W1999952230 hasPublicationYear "2004" @default.
- W1999952230 type Work @default.
- W1999952230 sameAs 1999952230 @default.
- W1999952230 citedByCount "100" @default.
- W1999952230 countsByYear W19999522302012 @default.
- W1999952230 countsByYear W19999522302013 @default.
- W1999952230 countsByYear W19999522302014 @default.
- W1999952230 countsByYear W19999522302015 @default.
- W1999952230 countsByYear W19999522302016 @default.
- W1999952230 countsByYear W19999522302017 @default.
- W1999952230 countsByYear W19999522302018 @default.
- W1999952230 countsByYear W19999522302019 @default.
- W1999952230 countsByYear W19999522302020 @default.
- W1999952230 countsByYear W19999522302021 @default.
- W1999952230 countsByYear W19999522302022 @default.
- W1999952230 countsByYear W19999522302023 @default.
- W1999952230 crossrefType "journal-article" @default.
- W1999952230 hasAuthorship W1999952230A5045418636 @default.
- W1999952230 hasAuthorship W1999952230A5049835071 @default.
- W1999952230 hasAuthorship W1999952230A5074245378 @default.
- W1999952230 hasAuthorship W1999952230A5081040498 @default.
- W1999952230 hasConcept C108204754 @default.
- W1999952230 hasConcept C124681953 @default.
- W1999952230 hasConcept C134121241 @default.
- W1999952230 hasConcept C142724271 @default.
- W1999952230 hasConcept C178790620 @default.
- W1999952230 hasConcept C179104552 @default.
- W1999952230 hasConcept C184651966 @default.
- W1999952230 hasConcept C185592680 @default.
- W1999952230 hasConcept C191897082 @default.
- W1999952230 hasConcept C192562407 @default.
- W1999952230 hasConcept C204787440 @default.
- W1999952230 hasConcept C2776142628 @default.
- W1999952230 hasConcept C2776910235 @default.
- W1999952230 hasConcept C2778063876 @default.
- W1999952230 hasConcept C71924100 @default.
- W1999952230 hasConcept C75473681 @default.
- W1999952230 hasConceptScore W1999952230C108204754 @default.
- W1999952230 hasConceptScore W1999952230C124681953 @default.
- W1999952230 hasConceptScore W1999952230C134121241 @default.
- W1999952230 hasConceptScore W1999952230C142724271 @default.
- W1999952230 hasConceptScore W1999952230C178790620 @default.
- W1999952230 hasConceptScore W1999952230C179104552 @default.