Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999966087> ?p ?o ?g. }
- W1999966087 endingPage "703" @default.
- W1999966087 startingPage "695" @default.
- W1999966087 abstract "1 The ability of adenosine and structurally-related compounds to inhibit epileptiform activity induced by bicuculline in the CA3 region of the hippocampal slice of the rat was examined. 2 Bath application of all purinoceptor agonists tested reduced the frequency of generation of burst potentials. Analysis of dose-response curves yielded the following IC50 values: adenosine, 1.5 μm; 2-chloroadenosine, 0.144 μm; 5′-(N-ethyl)carboxamidoadenosine, 30.2 nm; L-phenylisopropyladenosine, 12.1 nm; cyclohexyladenosine, 7.9 nm. 3 Theophylline (30 μm) increased the rate of bursting and antagonized the effect of exogenous adenosine. 4 Dipyridamole (0.03–1 μm) reduced the occurrence of burst firing. 5 In slices untreated with bicuculline, theophylline (30 μm) and adenosine deaminase (10 μg ml−1) induced bursting activity. 6 These results demonstrate that purinoceptor agonists can suppress epileptiform activity in the hippocampus and suggest that adenosine may act as an endogenous anticonvulsant." @default.
- W1999966087 created "2016-06-24" @default.
- W1999966087 creator A5013215697 @default.
- W1999966087 creator A5024497258 @default.
- W1999966087 date "1986-05-01" @default.
- W1999966087 modified "2023-09-29" @default.
- W1999966087 title "Adenosine inhibits epileptiform activity arising in hippocampal area CA3" @default.
- W1999966087 cites W1497597874 @default.
- W1999966087 cites W1572160436 @default.
- W1999966087 cites W1829913204 @default.
- W1999966087 cites W1974864403 @default.
- W1999966087 cites W1982888042 @default.
- W1999966087 cites W1984975608 @default.
- W1999966087 cites W1985106862 @default.
- W1999966087 cites W1985575783 @default.
- W1999966087 cites W1986060126 @default.
- W1999966087 cites W1986668780 @default.
- W1999966087 cites W1990182385 @default.
- W1999966087 cites W1990302758 @default.
- W1999966087 cites W1994090626 @default.
- W1999966087 cites W1997199005 @default.
- W1999966087 cites W1997912713 @default.
- W1999966087 cites W2001110103 @default.
- W1999966087 cites W2002453718 @default.
- W1999966087 cites W2003277328 @default.
- W1999966087 cites W2005148909 @default.
- W1999966087 cites W2007462827 @default.
- W1999966087 cites W2013117701 @default.
- W1999966087 cites W2019935384 @default.
- W1999966087 cites W2025752096 @default.
- W1999966087 cites W2025894284 @default.
- W1999966087 cites W2031734647 @default.
- W1999966087 cites W2032922382 @default.
- W1999966087 cites W2040460480 @default.
- W1999966087 cites W2042052682 @default.
- W1999966087 cites W2045209711 @default.
- W1999966087 cites W2055155319 @default.
- W1999966087 cites W2055991501 @default.
- W1999966087 cites W2058080006 @default.
- W1999966087 cites W2059385437 @default.
- W1999966087 cites W2062589929 @default.
- W1999966087 cites W2069108499 @default.
- W1999966087 cites W2071161962 @default.
- W1999966087 cites W2072932124 @default.
- W1999966087 cites W2080561657 @default.
- W1999966087 cites W2083068856 @default.
- W1999966087 cites W2083954196 @default.
- W1999966087 cites W2088597267 @default.
- W1999966087 cites W2089553401 @default.
- W1999966087 cites W2090865448 @default.
- W1999966087 cites W2097694278 @default.
- W1999966087 cites W2107208063 @default.
- W1999966087 cites W2158586551 @default.
- W1999966087 cites W2234047440 @default.
- W1999966087 cites W2243606337 @default.
- W1999966087 cites W2320058521 @default.
- W1999966087 cites W2329605444 @default.
- W1999966087 cites W2344349459 @default.
- W1999966087 cites W2412877205 @default.
- W1999966087 cites W2436840850 @default.
- W1999966087 cites W2887002105 @default.
- W1999966087 cites W4300605218 @default.
- W1999966087 cites W55445163 @default.
- W1999966087 doi "https://doi.org/10.1111/j.1476-5381.1986.tb14587.x" @default.
- W1999966087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1916812" @default.
- W1999966087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3011169" @default.
- W1999966087 hasPublicationYear "1986" @default.
- W1999966087 type Work @default.
- W1999966087 sameAs 1999966087 @default.
- W1999966087 citedByCount "97" @default.
- W1999966087 countsByYear W19999660872012 @default.
- W1999966087 countsByYear W19999660872014 @default.
- W1999966087 countsByYear W19999660872015 @default.
- W1999966087 countsByYear W19999660872016 @default.
- W1999966087 countsByYear W19999660872017 @default.
- W1999966087 countsByYear W19999660872019 @default.
- W1999966087 countsByYear W19999660872020 @default.
- W1999966087 countsByYear W19999660872023 @default.
- W1999966087 crossrefType "journal-article" @default.
- W1999966087 hasAuthorship W1999966087A5013215697 @default.
- W1999966087 hasAuthorship W1999966087A5024497258 @default.
- W1999966087 hasBestOaLocation W19999660871 @default.
- W1999966087 hasConcept C126322002 @default.
- W1999966087 hasConcept C134018914 @default.
- W1999966087 hasConcept C148762608 @default.
- W1999966087 hasConcept C169760540 @default.
- W1999966087 hasConcept C170493617 @default.
- W1999966087 hasConcept C185592680 @default.
- W1999966087 hasConcept C195221683 @default.
- W1999966087 hasConcept C2775858608 @default.
- W1999966087 hasConcept C2776885963 @default.
- W1999966087 hasConcept C2776991684 @default.
- W1999966087 hasConcept C2776992512 @default.
- W1999966087 hasConcept C2778095195 @default.
- W1999966087 hasConcept C2778186239 @default.
- W1999966087 hasConcept C2778938600 @default.
- W1999966087 hasConcept C2780763569 @default.
- W1999966087 hasConcept C34628245 @default.