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- W1999966361 abstract "by hyperemia and mucosal thickness and weight lose. On day 3 after colitis induction, 66% and 16% of Desnosumab-DSS-treated mice had weight loss and mucosal thickening respectively, compared to 100% and 66% of vehicle DSS-treated mice (p<0.05). Composite macroscopic score was 41% lower in Desnosumab-DSS-treated mice than in vehicle DSStreated mice (p<0.05). All four markers including diarrhea, hyperemia, thickness and adhesion were decreased. Denosumab treatment decreased the colonic MPO activity (p<0.05). Colonic IL-1b levels decreased from 41.1±1.7 in vehicle-DSS-treated mice to 13.11±1.3 pg/ mg of tissue in Denosumab-DSS-treated mice (p<0.05). Conversely, no effect was evident on colonic IL-6 levels. In control mice (without colitis) Denosumab did not affect any inflammatory marker. Conclusions: These results support the hypothesis that preventative treatment with Denosumab modulates intestinal inflammation in a murine model of colitis. This provides a rationale for considering Denosumab as a therapy in CD." @default.
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- W1999966361 date "2015-04-01" @default.
- W1999966361 modified "2023-09-25" @default.
- W1999966361 title "Mo1700 Targeted Topical Therapy to Treat Inflammatory Bowel Disease Using a Novel Thermosensitive Drug Delivery Platform" @default.
- W1999966361 doi "https://doi.org/10.1016/s0016-5085(15)32330-1" @default.
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