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• W1999968946 endingPage "e10181" @default.
• W1999968946 startingPage "e10181" @default.
• W1999968946 abstract "Many gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is usually flanked N-terminally by arginine and C-terminally by valine. We used this 14-residue sequence as a template to create a small library of peptides that bind cholesterol and other lipids.Several of these peptides manifested anti-inflammatory properties in a predictive in vitro monocyte chemotactic assay, and some also diminished the pro-inflammatory effects of low-density lipoprotein in apoE-deficient mice. The most potent analog, Oxpholipin-11D (OxP-11D), contained D-amino acids exclusively and was identical to the 14-residue design template except that diphenylalanine replaced cysteine-3. In surface plasmon resonance binding studies, OxP-11D bound oxidized (phospho)lipids and sterols in much the same manner as D-4F, a widely studied cardioprotective apoA-I-mimetic peptide with anti-inflammatory properties. In contrast to D-4F, which adopts a stable alpha-helical structure in solution, the OxP-11D structure was flexible and contained multiple turn-like features.Given the substantial evidence that oxidized phospholipids are pro-inflammatory in vivo, OxP-11D and other Oxpholipins may have therapeutic potential." @default.
• W1999968946 created "2016-06-24" @default.
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• W1999968946 date "2010-04-14" @default.
• W1999968946 modified "2023-10-14" @default.
• W1999968946 title "Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids" @default.
• W1999968946 cites W1509346516 @default.
• W1999968946 cites W1966078827 @default.
• W1999968946 cites W1968647954 @default.
• W1999968946 cites W1972751508 @default.
• W1999968946 cites W1972784152 @default.
• W1999968946 cites W1974455553 @default.
• W1999968946 cites W1976697224 @default.
• W1999968946 cites W1978904473 @default.
• W1999968946 cites W1980832959 @default.
• W1999968946 cites W1982004996 @default.
• W1999968946 cites W1989984065 @default.
• W1999968946 cites W1990632046 @default.
• W1999968946 cites W1995370296 @default.
• W1999968946 cites W1995799117 @default.
• W1999968946 cites W1996866382 @default.
• W1999968946 cites W1999974293 @default.
• W1999968946 cites W2004767898 @default.
• W1999968946 cites W2004782220 @default.
• W1999968946 cites W2006212946 @default.
• W1999968946 cites W2006791133 @default.
• W1999968946 cites W2007923434 @default.
• W1999968946 cites W2008708467 @default.
• W1999968946 cites W2013999949 @default.
• W1999968946 cites W2024176341 @default.
• W1999968946 cites W2028089693 @default.
• W1999968946 cites W2028339142 @default.
• W1999968946 cites W2033098486 @default.
• W1999968946 cites W2037455416 @default.
• W1999968946 cites W2038857982 @default.
• W1999968946 cites W2043482436 @default.
• W1999968946 cites W2044112399 @default.
• W1999968946 cites W2046432808 @default.
• W1999968946 cites W2053131885 @default.
• W1999968946 cites W2054537071 @default.
• W1999968946 cites W2056993355 @default.
• W1999968946 cites W2060372676 @default.
• W1999968946 cites W2062102053 @default.
• W1999968946 cites W2062251043 @default.
• W1999968946 cites W2062673333 @default.
• W1999968946 cites W2069973568 @default.
• W1999968946 cites W2078078010 @default.
• W1999968946 cites W2078802769 @default.
• W1999968946 cites W2083957918 @default.
• W1999968946 cites W2084932614 @default.
• W1999968946 cites W2090470056 @default.
• W1999968946 cites W2095507444 @default.
• W1999968946 cites W2100865709 @default.
• W1999968946 cites W2101092993 @default.
• W1999968946 cites W2102505603 @default.
• W1999968946 cites W2103080864 @default.
• W1999968946 cites W2104017463 @default.
• W1999968946 cites W2105662647 @default.
• W1999968946 cites W2106668238 @default.
• W1999968946 cites W2108315457 @default.
• W1999968946 cites W2109225320 @default.
• W1999968946 cites W2110031410 @default.
• W1999968946 cites W2112187949 @default.
• W1999968946 cites W2112898910 @default.
• W1999968946 cites W2115420718 @default.
• W1999968946 cites W2122673417 @default.
• W1999968946 cites W2126007462 @default.
• W1999968946 cites W2127329933 @default.
• W1999968946 cites W2128157898 @default.
• W1999968946 cites W2137951377 @default.
• W1999968946 cites W2148863905 @default.
• W1999968946 cites W2166525518 @default.
• W1999968946 cites W2166807768 @default.
• W1999968946 cites W2185709413 @default.
• W1999968946 cites W2326849545 @default.
• W1999968946 cites W2397723481 @default.
• W1999968946 cites W2399340779 @default.
• W1999968946 cites W2626246102 @default.
• W1999968946 cites W35493299 @default.
• W1999968946 cites W43234961 @default.
• W1999968946 cites W76508086 @default.
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• W1999968946 doi "https://doi.org/10.1371/journal.pone.0010181" @default.
• W1999968946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854715" @default.
• W1999968946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20418958" @default.
• W1999968946 hasPublicationYear "2010" @default.
• W1999968946 type Work @default.
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