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• W1999972637 abstract "This study determined if in vitro transfer of drug complexes across the everted rat small intestine would reflect the in vivo absorption characteristics of the complex. The in vitro transfer of prednisolone in the presence of dimethyl-, diethyl-, dipropyl-, and dibutylpropionamide was in rank-order agreement with the increase in absorption reported previously from an in situ preparation. Excellent agreement was found between the in vitro and in situ absorption of prednisolone in the presence of various concentrations of dipropylpropionamide. The interaction of atropine with eosin-B, which has been reported not to increase the transfer of the dye across the everted rat intestine, was found to have no effect on absorption from an in situ preparation. The difference in effect of complexation on drug transfer across the everted rat intestine may be related to a difference in rate-limiting barriers for prednisolone and eosin-B." @default.
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• W1999972637 date "1974-03-01" @default.
• W1999972637 modified "2023-09-26" @default.
• W1999972637 title "In vitro assessment of in vivo absorption of drug complexes." @default.
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