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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999984826> ?p ?o ?g. }

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• W1999984826 abstract "Phospholipases A2 (PLA2) play an important role in Toxoplasmagondii host cell penetration. They are also key enzymes in the host cell response to the parasite invasion. PLA2 hydrolyse cellular phospholipids, releasing multiple inflammatory lipidic mediators. We have investigated the biochemical characterisation of T. gondii PLA2 activity in a mouse-cultured tachyzoite homogenate and in the peritoneal exudate from infected mice, using the hydrolysis of a fluorescent phosphatidylglycerol labelled at the sn-2 position. Spectrofluorimetry and thin-layer chromatography showed a PLA2 activity (about 0.5–2 nmol/min per mg), calcium-independent, secreted into infected mice peritoneal exudate, with a broad pH activity ranging between 6.5 and 9.5 and resistant to a great number of potential PLA2 inhibitors except dithio-nitrobenzoic acid (1 mM). An associated phospholipase A1 activity was also displayed. These results suggest that Toxoplasma gondii displays specific phospholipases different from host enzymes and probably involved at critical steps of infectious cycle." @default.
• W1999984826 created "2016-06-24" @default.
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• W1999984826 date "2000-10-01" @default.
• W1999984826 modified "2023-10-17" @default.
• W1999984826 title "Toxoplasma gondii secretes a calcium-independent phospholipase A 2" @default.
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• W1999984826 doi "https://doi.org/10.1016/s0020-7519(00)00101-6" @default.
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