FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999990769> ?p ?o ?g. }

• W1999990769 abstract "The release of endogenous acetylcholine was measured in electrically (5-20 Hz) stimulated guinea pig cerebral cortex and caudate nucleus slices under ischemic (hypoxic and glucose-free) conditions. Ischemia reduced acetylcholine release by 40-90%; the inhibition depended on the duration of ischemia (10-30 min) while the extent of post-ischemic recovery was inversely related to it. Caudate nucleus slices displayed a higher sensitivity to ischemia than did cortical slices. To test the effects of excitatory amino acid receptor antagonists on the ischemia-induced reduction of acetylcoline release and on its post-ischemic recovery, the following drugs were used: 5-methyl-10,11-dihydro-5-H-dibenzo-[a,b]-cyclohepten-5,10-imine (MK-801,-a blocker of the N-methyl-D-aspartate [NMDA] receptor-linked channel), 7-chloro-kynurenic acid (7-Cl-KYN) and (E)-3-[2(phenylcarbamoyl)ethenyl]-4,6-dichloroindole-2-carboxylic acid sodium salt (GV150526A, blockers of the glycine site of the NMDA receptor), eliprodil, (an antagonist at the polyamine site of the NMDA receptor), and 6-cyano- 7-nitro-quinoxalin-2,3-dione (CNQX, a D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid [AMPA] receptor antagonist). These did not modify the time-course and the extent of ischemia-induced inhibition but improved post-ischemic recovery in a concentration dependent manner. GV 150526A and CNQX appeared to be more effective in the cerebral cortex. Only eliprodil was devoid of any effect in both areas. The evaluation of acetylcholine release from brain slices represents a suitable in vitro model to quantify the effectiveness of drugs in favouring recovery from the cholinergic presynaptic failure induced by ischemic conditions. The different effects of the excitatory amino acid receptor antagonists cited above, depending on the brain areas considered and the receptor subtypes involved, may be of interest in view of their therapeutic potential." @default.
• W1999990769 created "2016-06-24" @default.
• W1999990769 creator A5038385892 @default.
• W1999990769 creator A5059286248 @default.
• W1999990769 creator A5061581264 @default.
• W1999990769 creator A5072959938 @default.
• W1999990769 creator A5089708931 @default.
• W1999990769 date "1997-12-01" @default.
• W1999990769 modified "2023-09-25" @default.
• W1999990769 title "Post-ischemic recovery of acetylcholine release in vitro: influence of different excitatory amino acid receptor subtype antagonists" @default.
• W1999990769 cites W1508421599 @default.
• W1999990769 cites W1899736663 @default.
• W1999990769 cites W1980484115 @default.
• W1999990769 cites W1982395498 @default.
• W1999990769 cites W1982576487 @default.
• W1999990769 cites W1983633750 @default.
• W1999990769 cites W1988240074 @default.
• W1999990769 cites W1991542726 @default.
• W1999990769 cites W1997164821 @default.
• W1999990769 cites W2006276116 @default.
• W1999990769 cites W2008351358 @default.
• W1999990769 cites W2013044638 @default.
• W1999990769 cites W2019099519 @default.
• W1999990769 cites W2022668453 @default.
• W1999990769 cites W2024173492 @default.
• W1999990769 cites W2034313686 @default.
• W1999990769 cites W2048964518 @default.
• W1999990769 cites W2052269200 @default.
• W1999990769 cites W2057009745 @default.
• W1999990769 cites W2071961923 @default.
• W1999990769 cites W2125474172 @default.
• W1999990769 cites W2135389271 @default.
• W1999990769 doi "https://doi.org/10.1016/s0197-0186(97)00024-7" @default.
• W1999990769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9413843" @default.
• W1999990769 hasPublicationYear "1997" @default.
• W1999990769 type Work @default.
• W1999990769 sameAs 1999990769 @default.
• W1999990769 citedByCount "14" @default.
• W1999990769 countsByYear W19999907692013 @default.
• W1999990769 countsByYear W19999907692021 @default.
• W1999990769 crossrefType "journal-article" @default.
• W1999990769 hasAuthorship W1999990769A5038385892 @default.
• W1999990769 hasAuthorship W1999990769A5059286248 @default.
• W1999990769 hasAuthorship W1999990769A5061581264 @default.
• W1999990769 hasAuthorship W1999990769A5072959938 @default.
• W1999990769 hasAuthorship W1999990769A5089708931 @default.
• W1999990769 hasConcept C160268369 @default.
• W1999990769 hasConcept C170493617 @default.
• W1999990769 hasConcept C185592680 @default.
• W1999990769 hasConcept C2775910092 @default.
• W1999990769 hasConcept C2776841986 @default.
• W1999990769 hasConcept C2776885963 @default.
• W1999990769 hasConcept C2778122271 @default.
• W1999990769 hasConcept C2779803574 @default.
• W1999990769 hasConcept C55493867 @default.
• W1999990769 hasConcept C67018056 @default.
• W1999990769 hasConcept C86803240 @default.
• W1999990769 hasConcept C98274493 @default.
• W1999990769 hasConceptScore W1999990769C160268369 @default.
• W1999990769 hasConceptScore W1999990769C170493617 @default.
• W1999990769 hasConceptScore W1999990769C185592680 @default.
• W1999990769 hasConceptScore W1999990769C2775910092 @default.
• W1999990769 hasConceptScore W1999990769C2776841986 @default.
• W1999990769 hasConceptScore W1999990769C2776885963 @default.
• W1999990769 hasConceptScore W1999990769C2778122271 @default.
• W1999990769 hasConceptScore W1999990769C2779803574 @default.
• W1999990769 hasConceptScore W1999990769C55493867 @default.
• W1999990769 hasConceptScore W1999990769C67018056 @default.
• W1999990769 hasConceptScore W1999990769C86803240 @default.
• W1999990769 hasConceptScore W1999990769C98274493 @default.
• W1999990769 hasLocation W19999907691 @default.
• W1999990769 hasLocation W19999907692 @default.
• W1999990769 hasOpenAccess W1999990769 @default.
• W1999990769 hasPrimaryLocation W19999907691 @default.
• W1999990769 hasRelatedWork W1994868166 @default.
• W1999990769 hasRelatedWork W1999990769 @default.
• W1999990769 hasRelatedWork W2012460669 @default.
• W1999990769 hasRelatedWork W2015172542 @default.
• W1999990769 hasRelatedWork W2038041346 @default.
• W1999990769 hasRelatedWork W2056933680 @default.
• W1999990769 hasRelatedWork W2066622964 @default.
• W1999990769 hasRelatedWork W2325077172 @default.
• W1999990769 hasRelatedWork W2813089312 @default.
• W1999990769 hasRelatedWork W4283522590 @default.
• W1999990769 isParatext "false" @default.
• W1999990769 isRetracted "false" @default.
• W1999990769 magId "1999990769" @default.
• W1999990769 workType "article" @default.