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- W2000001904 abstract "Schut et al.1 reported 6 patients who had ischemic stroke 7–30 days after initially good recovery from pneumococcal meningitis (PM). All patients were treated with adjunctive corticosteroids. Based on autopsy findings in 2 patients, Schut et al. proposed that stroke is caused by delayed cerebral thrombosis—not by vasculitis—and possibly related to adjunctive corticosteroid therapy.Stroke is a well-known complication of PM, but the definite timing of stroke onset and its association with initial therapy are unknown.2 We reanalyzed data of 17 previously published patients with ischemic stroke complicating PM3 focusing on timing of stroke onset, initial corticosteroid therapy, and causes of stroke.Median onset of stroke was 4 (0–50) days after initiation of therapy. In 5 cases, stroke occurred 6–10 days after initiation of antibiotic therapy and in another 5 cases after more than 10 days. CSF parameters had initially improved in all 10 patients with stroke occurring at least 6 days after therapy was started. However, most of them were severely affected. Seven out of 10 were still comatose or sedated and only 3 out of 10 were following commands at stroke onset. Signs of narrowing of cerebral arteries were detected in 8 out of 10 patients (2 of them receiving corticosteroids) by conventional angiography,5 …" @default.
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- W2000001904 date "2010-07-12" @default.
- W2000001904 modified "2023-10-13" @default.
- W2000001904 title "DELAYED CEREBRAL THROMBOSIS AFTER INITIAL GOOD RECOVERY FROM PNEUMOCOCCAL MENINGITIS" @default.
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- W2000001904 doi "https://doi.org/10.1212/wnl.0b013e3181e00e8e" @default.
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