Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000003423> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2000003423 endingPage "310" @default.
- W2000003423 startingPage "304" @default.
- W2000003423 abstract "In the microenvironment of many solid tumors the pH is considerably lower (mean pH between 6.6 to 7.2) than the pH in normal tissue (pH 7.0-7.5). Therefore, the influence of acidic pH on the cytotoxic activity of lymphokine-activated killer cells (LAK cells) after different culture periods was tested. K-562 human erythroleukemia cells were selected as target cells. Cell killing was measured using a two-color flow cytometric method. At physiological pH of 7.4, LAK cell-mediated cytotoxicity ranged from 15 to 48% (E:T ratio = 50:1). The specific lysis of target cells was considerably reduced (up to 70% inhibition of specific lysis) under acidic conditions (pH 6.8, 6.3, 5.8). This effect was independent of donors, duration of the culture period, and the E:T ratio in the cytotoxic assay. As pH gradients surrounding tumor cells may reach values below pH 6.0 at the cell surface, the pH-dependence of LAK cell cytotoxicity could at least partially explain the inhibition of the natural immune response in solid tumors. Therapeutic immunological strategies concerning the enhancement of the natural immune response like LAK cell and IL-2 immunotherapy including IL-2 gene therapy may only be successful if a simultaneous inhibition of the acidification process and an elevation of tumor pH is achieved." @default.
- W2000003423 created "2016-06-24" @default.
- W2000003423 creator A5033021691 @default.
- W2000003423 creator A5047506006 @default.
- W2000003423 creator A5051001507 @default.
- W2000003423 creator A5087076415 @default.
- W2000003423 creator A5087901904 @default.
- W2000003423 creator A5091231669 @default.
- W2000003423 creator A5046121187 @default.
- W2000003423 date "1994-01-01" @default.
- W2000003423 modified "2023-09-27" @default.
- W2000003423 title "pH-Dependent LAK Cell Cytotoxicity" @default.
- W2000003423 doi "https://doi.org/10.1159/000217905" @default.
- W2000003423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7991991" @default.
- W2000003423 hasPublicationYear "1994" @default.
- W2000003423 type Work @default.
- W2000003423 sameAs 2000003423 @default.
- W2000003423 citedByCount "48" @default.
- W2000003423 countsByYear W20000034232012 @default.
- W2000003423 countsByYear W20000034232015 @default.
- W2000003423 countsByYear W20000034232016 @default.
- W2000003423 countsByYear W20000034232017 @default.
- W2000003423 countsByYear W20000034232018 @default.
- W2000003423 countsByYear W20000034232019 @default.
- W2000003423 countsByYear W20000034232020 @default.
- W2000003423 countsByYear W20000034232021 @default.
- W2000003423 countsByYear W20000034232022 @default.
- W2000003423 countsByYear W20000034232023 @default.
- W2000003423 crossrefType "journal-article" @default.
- W2000003423 hasAuthorship W2000003423A5033021691 @default.
- W2000003423 hasAuthorship W2000003423A5046121187 @default.
- W2000003423 hasAuthorship W2000003423A5047506006 @default.
- W2000003423 hasAuthorship W2000003423A5051001507 @default.
- W2000003423 hasAuthorship W2000003423A5087076415 @default.
- W2000003423 hasAuthorship W2000003423A5087901904 @default.
- W2000003423 hasAuthorship W2000003423A5091231669 @default.
- W2000003423 hasConcept C109316439 @default.
- W2000003423 hasConcept C1491633281 @default.
- W2000003423 hasConcept C149532602 @default.
- W2000003423 hasConcept C153911025 @default.
- W2000003423 hasConcept C154317977 @default.
- W2000003423 hasConcept C185592680 @default.
- W2000003423 hasConcept C202751555 @default.
- W2000003423 hasConcept C203014093 @default.
- W2000003423 hasConcept C2777701055 @default.
- W2000003423 hasConcept C2778102761 @default.
- W2000003423 hasConcept C28651165 @default.
- W2000003423 hasConcept C49382859 @default.
- W2000003423 hasConcept C54355233 @default.
- W2000003423 hasConcept C55493867 @default.
- W2000003423 hasConcept C57409179 @default.
- W2000003423 hasConcept C81885089 @default.
- W2000003423 hasConcept C86803240 @default.
- W2000003423 hasConcept C8891405 @default.
- W2000003423 hasConceptScore W2000003423C109316439 @default.
- W2000003423 hasConceptScore W2000003423C1491633281 @default.
- W2000003423 hasConceptScore W2000003423C149532602 @default.
- W2000003423 hasConceptScore W2000003423C153911025 @default.
- W2000003423 hasConceptScore W2000003423C154317977 @default.
- W2000003423 hasConceptScore W2000003423C185592680 @default.
- W2000003423 hasConceptScore W2000003423C202751555 @default.
- W2000003423 hasConceptScore W2000003423C203014093 @default.
- W2000003423 hasConceptScore W2000003423C2777701055 @default.
- W2000003423 hasConceptScore W2000003423C2778102761 @default.
- W2000003423 hasConceptScore W2000003423C28651165 @default.
- W2000003423 hasConceptScore W2000003423C49382859 @default.
- W2000003423 hasConceptScore W2000003423C54355233 @default.
- W2000003423 hasConceptScore W2000003423C55493867 @default.
- W2000003423 hasConceptScore W2000003423C57409179 @default.
- W2000003423 hasConceptScore W2000003423C81885089 @default.
- W2000003423 hasConceptScore W2000003423C86803240 @default.
- W2000003423 hasConceptScore W2000003423C8891405 @default.
- W2000003423 hasIssue "5" @default.
- W2000003423 hasLocation W20000034231 @default.
- W2000003423 hasLocation W20000034232 @default.
- W2000003423 hasOpenAccess W2000003423 @default.
- W2000003423 hasPrimaryLocation W20000034231 @default.
- W2000003423 hasRelatedWork W1543053641 @default.
- W2000003423 hasRelatedWork W1547376927 @default.
- W2000003423 hasRelatedWork W1965995080 @default.
- W2000003423 hasRelatedWork W2039747916 @default.
- W2000003423 hasRelatedWork W2065973567 @default.
- W2000003423 hasRelatedWork W2080674449 @default.
- W2000003423 hasRelatedWork W2423148672 @default.
- W2000003423 hasRelatedWork W4251449568 @default.
- W2000003423 hasRelatedWork W4313311385 @default.
- W2000003423 hasRelatedWork W2185779647 @default.
- W2000003423 hasVolume "15" @default.
- W2000003423 isParatext "false" @default.
- W2000003423 isRetracted "false" @default.
- W2000003423 magId "2000003423" @default.
- W2000003423 workType "article" @default.