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• W2000007533 abstract "Filipendula kamtschatica is a plant utilized as a traditional medicine by Ainu people in Japan, but its chemical constituents are not much studied. Pancreatic lipase inhibitors are a promising tool for the treatment of obesity. We searched for natural lipase inhibitors from F. kamtschatica and two new compounds were isolated along with the known flavonoid glycoside. The structure elucidation of new compounds revealed these two to be 2-O-caffeoyl-4-O-galloyl-l-threonic acid and 3-O-caffeoyl-4-O-galloyl-l-threonic acid, which can be recognized as a pancreatic lipase’s substrate-like structure. The isolated compounds all showed an inhibitory activity against porcine pancreatic lipase and one of the isomer, 3-O-caffeoyl-4-O-galloyl-l-threonic acid, possessed the most potent activity with IC50 value showing an order lower value compared to others. The substrate-like structure of the new compounds seemed to be important for their activity." @default.
• W2000007533 created "2016-06-24" @default.
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• W2000007533 date "2012-10-01" @default.
• W2000007533 modified "2023-09-29" @default.
• W2000007533 title "Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica" @default.
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• W2000007533 doi "https://doi.org/10.1016/j.bmcl.2012.08.055" @default.
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