FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000009747> ?p ?o ?g. }

• W2000009747 endingPage "294" @default.
• W2000009747 startingPage "285" @default.
• W2000009747 abstract "There were many reports on the neutralization test of poliomyelitis (polio) virus before 1939, as well as on the relationship between the neutralizing antibody and the illness. The animals available for the experiments of polio were only monkey before 1939, so that in any experiment animals were not used enough to estimate accurately the blood level of antibody because of their expense. However since Armstrong (1) was successful to transfer the “Lansing” strain of polio virus which had been isolated in monkey, first to the cotton rat and then to the swiss mouse, many mice were used for the neutralization test against the mouse-adapted strain, and the result would be more precise to discuss on the neutralizing antibody on the polio case.It is well known that the higher positive rate of neutralization test of human sera against the “Lansing” strain of polio virus are found in the older age groups according to Turner (2) and Pait (3), the sera of 80% of children, less than 6 months old are capable of neutralizing the virus, while children from 6 months to 2 years of age have the positive rate in 20-30 per cent. With advances in ages an increasing percentages of individuals become positive in this test, and the sera of children between thee age of eight and twelve years have this property in 80%.It was pointed out by Paul (4) that Japan was strongly contaminated by polio virus due to her poor sanitary condition. Well it is very important to determine how many Japanese in each age group has a neutralizing antibody against the mouse-adapted “Lansing” strain of polio virus following the subclinical infection.The methods of neutralization test used by ntiany authors are not the same. They are summarized principally in the following :1) by mixing the same quantities of undiluted serum and suspension of infects mouse brain and spinal cozd known to be active, 2) by mixing the same virus with sera 10, 3.2 or 2 fold diluted, 3) by mixing a series of 10 fold diluted virus with undiluted sera, 4) by mixing a series of 10 fold diluted virus with sera 10, 3.2 or 2 fold diluted.Such mixtures are generally incubated for two hours and then injected intracerebrally into each group of mice.Method 1) is the most simple and generally used. The point is that the virus employed in each experiment should be the same in an adequate virulence. For this purpose the virus emulsion should be kept in dry ice box in sealed ampules. If the virus is not of the same virulence it is impossible to compare the results obtained by many authors each other. For example Turner (5) used the virus suspension of 180 LD50, Hammon (6) and Morgan (7) 10 LD50 and Pait (3) 32 LD50-. Method 2) is used to determine the titer of positive serum. Method 3) is for the determination of the negative serum. Method 4) isacombination of 2) and 3) . One example is shown in Table 1. Method 3) is generally used by us and sometimes combined with method 4) ." @default.
• W2000009747 created "2016-06-24" @default.
• W2000009747 creator A5023192012 @default.
• W2000009747 creator A5041374401 @default.
• W2000009747 date "1950-01-01" @default.
• W2000009747 modified "2023-09-26" @default.
• W2000009747 title "THE NEUTRALIZATION TEST OF NORMAL AND CONVALESCENT HUMAN SERA IN TOKYO, AGAINST THE MOUSE-ADAPTED POLIOMYELITIS VIRUS ^|^ldquo;LANSING^|^rdquo; STRAIN" @default.
• W2000009747 cites W2142761032 @default.
• W2000009747 cites W2199796937 @default.
• W2000009747 cites W2264365209 @default.
• W2000009747 cites W2314478294 @default.
• W2000009747 cites W2327964562 @default.
• W2000009747 cites W2342313205 @default.
• W2000009747 cites W2345203270 @default.
• W2000009747 cites W2420887197 @default.
• W2000009747 cites W2800160896 @default.
• W2000009747 doi "https://doi.org/10.7883/yoken1948.2.285" @default.
• W2000009747 hasPublicationYear "1950" @default.
• W2000009747 type Work @default.
• W2000009747 sameAs 2000009747 @default.
• W2000009747 citedByCount "3" @default.
• W2000009747 crossrefType "journal-article" @default.
• W2000009747 hasAuthorship W2000009747A5023192012 @default.
• W2000009747 hasAuthorship W2000009747A5041374401 @default.
• W2000009747 hasBestOaLocation W20000097471 @default.
• W2000009747 hasConcept C126322002 @default.
• W2000009747 hasConcept C14086860 @default.
• W2000009747 hasConcept C159047783 @default.
• W2000009747 hasConcept C159654299 @default.
• W2000009747 hasConcept C203014093 @default.
• W2000009747 hasConcept C2522874641 @default.
• W2000009747 hasConcept C2778022156 @default.
• W2000009747 hasConcept C2779261636 @default.
• W2000009747 hasConcept C2779631682 @default.
• W2000009747 hasConcept C4870876 @default.
• W2000009747 hasConcept C71924100 @default.
• W2000009747 hasConceptScore W2000009747C126322002 @default.
• W2000009747 hasConceptScore W2000009747C14086860 @default.
• W2000009747 hasConceptScore W2000009747C159047783 @default.
• W2000009747 hasConceptScore W2000009747C159654299 @default.
• W2000009747 hasConceptScore W2000009747C203014093 @default.
• W2000009747 hasConceptScore W2000009747C2522874641 @default.
• W2000009747 hasConceptScore W2000009747C2778022156 @default.
• W2000009747 hasConceptScore W2000009747C2779261636 @default.
• W2000009747 hasConceptScore W2000009747C2779631682 @default.
• W2000009747 hasConceptScore W2000009747C4870876 @default.
• W2000009747 hasConceptScore W2000009747C71924100 @default.
• W2000009747 hasIssue "6" @default.
• W2000009747 hasLocation W20000097471 @default.
• W2000009747 hasOpenAccess W2000009747 @default.
• W2000009747 hasPrimaryLocation W20000097471 @default.
• W2000009747 hasRelatedWork W1500614447 @default.
• W2000009747 hasRelatedWork W1523936328 @default.
• W2000009747 hasRelatedWork W1617171147 @default.
• W2000009747 hasRelatedWork W2044481028 @default.
• W2000009747 hasRelatedWork W2071385834 @default.
• W2000009747 hasRelatedWork W2139983200 @default.
• W2000009747 hasRelatedWork W2325710344 @default.
• W2000009747 hasRelatedWork W2415735992 @default.
• W2000009747 hasRelatedWork W2471897432 @default.
• W2000009747 hasRelatedWork W2745086030 @default.
• W2000009747 hasVolume "2" @default.
• W2000009747 isParatext "false" @default.
• W2000009747 isRetracted "false" @default.
• W2000009747 magId "2000009747" @default.
• W2000009747 workType "article" @default.