Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000022451> ?p ?o ?g. }
- W2000022451 endingPage "564" @default.
- W2000022451 startingPage "551" @default.
- W2000022451 abstract "The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here, we report that the multisubunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha-tubulin. Reduction of alpha-tubulin acetylation via expression of a nonacetylatable alpha-tubulin mutant leads to comparable defects in cortical neurons and suggests that alpha-tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha-tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons." @default.
- W2000022451 created "2016-06-24" @default.
- W2000022451 creator A5003786275 @default.
- W2000022451 creator A5009843959 @default.
- W2000022451 creator A5022690172 @default.
- W2000022451 creator A5029040383 @default.
- W2000022451 creator A5029427610 @default.
- W2000022451 creator A5030325551 @default.
- W2000022451 creator A5035104330 @default.
- W2000022451 creator A5039702458 @default.
- W2000022451 creator A5051558425 @default.
- W2000022451 creator A5057341523 @default.
- W2000022451 creator A5061226598 @default.
- W2000022451 creator A5061600171 @default.
- W2000022451 creator A5063268283 @default.
- W2000022451 creator A5064530192 @default.
- W2000022451 creator A5078000054 @default.
- W2000022451 creator A5083536847 @default.
- W2000022451 creator A5089388020 @default.
- W2000022451 date "2009-02-01" @default.
- W2000022451 modified "2023-10-12" @default.
- W2000022451 title "Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin" @default.
- W2000022451 cites W1977639025 @default.
- W2000022451 cites W1979832500 @default.
- W2000022451 cites W1981549228 @default.
- W2000022451 cites W1981753633 @default.
- W2000022451 cites W1982277306 @default.
- W2000022451 cites W1985425984 @default.
- W2000022451 cites W1988398725 @default.
- W2000022451 cites W1992502425 @default.
- W2000022451 cites W2012887006 @default.
- W2000022451 cites W2014288904 @default.
- W2000022451 cites W2014782860 @default.
- W2000022451 cites W2020346357 @default.
- W2000022451 cites W2021406306 @default.
- W2000022451 cites W2025909991 @default.
- W2000022451 cites W2025945768 @default.
- W2000022451 cites W2029130907 @default.
- W2000022451 cites W2031699523 @default.
- W2000022451 cites W2031817726 @default.
- W2000022451 cites W2040338904 @default.
- W2000022451 cites W2040531711 @default.
- W2000022451 cites W2043204105 @default.
- W2000022451 cites W2044227193 @default.
- W2000022451 cites W2046006859 @default.
- W2000022451 cites W2046746554 @default.
- W2000022451 cites W2048490262 @default.
- W2000022451 cites W2064959533 @default.
- W2000022451 cites W2068507797 @default.
- W2000022451 cites W2085600539 @default.
- W2000022451 cites W2088477641 @default.
- W2000022451 cites W2092908962 @default.
- W2000022451 cites W2092997991 @default.
- W2000022451 cites W2101127235 @default.
- W2000022451 cites W2103868443 @default.
- W2000022451 cites W2106579945 @default.
- W2000022451 cites W2115279938 @default.
- W2000022451 cites W2115551830 @default.
- W2000022451 cites W2117767933 @default.
- W2000022451 cites W2120042804 @default.
- W2000022451 cites W2122301474 @default.
- W2000022451 cites W2129250945 @default.
- W2000022451 cites W2134711325 @default.
- W2000022451 cites W2136015426 @default.
- W2000022451 cites W2137364646 @default.
- W2000022451 cites W2140045506 @default.
- W2000022451 cites W2140493425 @default.
- W2000022451 cites W2149695265 @default.
- W2000022451 cites W2151792462 @default.
- W2000022451 cites W2165105249 @default.
- W2000022451 cites W4230408874 @default.
- W2000022451 cites W4250943273 @default.
- W2000022451 doi "https://doi.org/10.1016/j.cell.2008.11.043" @default.
- W2000022451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19185337" @default.
- W2000022451 hasPublicationYear "2009" @default.
- W2000022451 type Work @default.
- W2000022451 sameAs 2000022451 @default.
- W2000022451 citedByCount "430" @default.
- W2000022451 countsByYear W20000224512012 @default.
- W2000022451 countsByYear W20000224512013 @default.
- W2000022451 countsByYear W20000224512014 @default.
- W2000022451 countsByYear W20000224512015 @default.
- W2000022451 countsByYear W20000224512016 @default.
- W2000022451 countsByYear W20000224512017 @default.
- W2000022451 countsByYear W20000224512018 @default.
- W2000022451 countsByYear W20000224512019 @default.
- W2000022451 countsByYear W20000224512020 @default.
- W2000022451 countsByYear W20000224512021 @default.
- W2000022451 countsByYear W20000224512022 @default.
- W2000022451 countsByYear W20000224512023 @default.
- W2000022451 crossrefType "journal-article" @default.
- W2000022451 hasAuthorship W2000022451A5003786275 @default.
- W2000022451 hasAuthorship W2000022451A5009843959 @default.
- W2000022451 hasAuthorship W2000022451A5022690172 @default.
- W2000022451 hasAuthorship W2000022451A5029040383 @default.
- W2000022451 hasAuthorship W2000022451A5029427610 @default.
- W2000022451 hasAuthorship W2000022451A5030325551 @default.
- W2000022451 hasAuthorship W2000022451A5035104330 @default.