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- W2000036071 startingPage "389" @default.
- W2000036071 abstract "Akt (also known as protein kinase B or PKB) is the major downstream nodal point of the PI3K signaling pathway. This pathway is a promising anticancer therapeutic target, because constitutive activation of the PI3K-Akt pathway is correlated with tumor development, progression, poor prognosis, and resistance to cancer therapies. The Akt serine/threonine kinase regulates diverse cellular functions including cell growth, proliferation, glucose metabolism, and survival. Although all three known Akt isoforms (Akt1-3) are encoded by separate genes, their amino acid sequences show a high degree of similarity. For this and other reasons, it has long been assumed that all three Akt isoforms are activated in the same way, and their functions largely overlap. However, accumulating lines of evidence now suggest that the three Akt isoforms might have unique modes of activation and many distinct functions. In particular, it has recently been found that the Akt isoforms are localized at different subcellular compartments in both adipocytes and cancer cells. In this review, we highlight the unique roles of each Akt isoform by introducing published data obtained from both in vitro and in vivo studies. We also discuss the significant potential of the Akt isoforms as effective anticancer therapeutic targets." @default.
- W2000036071 created "2016-06-24" @default.
- W2000036071 creator A5002979897 @default.
- W2000036071 creator A5028437967 @default.
- W2000036071 creator A5044748206 @default.
- W2000036071 date "2010-12-01" @default.
- W2000036071 modified "2023-09-27" @default.
- W2000036071 title "The Akt isoforms, their unique functions and potential as anticancer therapeutic targets" @default.
- W2000036071 cites W1487234933 @default.
- W2000036071 cites W1496902741 @default.
- W2000036071 cites W1509669696 @default.
- W2000036071 cites W1594020010 @default.
- W2000036071 cites W1607892649 @default.
- W2000036071 cites W1617532721 @default.
- W2000036071 cites W1625966995 @default.
- W2000036071 cites W1668086213 @default.
- W2000036071 cites W1678800844 @default.
- W2000036071 cites W1726025741 @default.
- W2000036071 cites W1791888878 @default.
- W2000036071 cites W1965506981 @default.
- W2000036071 cites W1967233323 @default.
- W2000036071 cites W1970751001 @default.
- W2000036071 cites W1972239225 @default.
- W2000036071 cites W1972943971 @default.
- W2000036071 cites W1975642651 @default.
- W2000036071 cites W1978625554 @default.
- W2000036071 cites W1978981032 @default.
- W2000036071 cites W1979909416 @default.
- W2000036071 cites W1981517713 @default.
- W2000036071 cites W1981711832 @default.
- W2000036071 cites W1982810858 @default.
- W2000036071 cites W1983516907 @default.
- W2000036071 cites W1983566655 @default.
- W2000036071 cites W1984621921 @default.
- W2000036071 cites W1984879511 @default.
- W2000036071 cites W1985749030 @default.
- W2000036071 cites W1986375034 @default.
- W2000036071 cites W1986744874 @default.
- W2000036071 cites W1989542499 @default.
- W2000036071 cites W1992787379 @default.
- W2000036071 cites W1995482311 @default.
- W2000036071 cites W1996695017 @default.
- W2000036071 cites W2004496585 @default.
- W2000036071 cites W2008720923 @default.
- W2000036071 cites W2009886463 @default.
- W2000036071 cites W2011282245 @default.
- W2000036071 cites W2013044317 @default.
- W2000036071 cites W2013084027 @default.
- W2000036071 cites W2013829707 @default.
- W2000036071 cites W2014031706 @default.
- W2000036071 cites W2015543753 @default.
- W2000036071 cites W2016503230 @default.
- W2000036071 cites W2016706952 @default.
- W2000036071 cites W2018023891 @default.
- W2000036071 cites W2018786910 @default.
- W2000036071 cites W2022114529 @default.
- W2000036071 cites W2022481874 @default.
- W2000036071 cites W2023348498 @default.
- W2000036071 cites W2024306318 @default.
- W2000036071 cites W2025486703 @default.
- W2000036071 cites W2028268047 @default.
- W2000036071 cites W2031198066 @default.
- W2000036071 cites W2031469256 @default.
- W2000036071 cites W2037308821 @default.
- W2000036071 cites W2040143421 @default.
- W2000036071 cites W2044552118 @default.
- W2000036071 cites W2047073581 @default.
- W2000036071 cites W2053073281 @default.
- W2000036071 cites W2053232597 @default.
- W2000036071 cites W2058138221 @default.
- W2000036071 cites W2058720172 @default.
- W2000036071 cites W2059221693 @default.
- W2000036071 cites W2059549347 @default.
- W2000036071 cites W2061312576 @default.
- W2000036071 cites W2062390485 @default.
- W2000036071 cites W2063013228 @default.
- W2000036071 cites W2064397254 @default.
- W2000036071 cites W2064592094 @default.
- W2000036071 cites W2066457776 @default.
- W2000036071 cites W2070643112 @default.
- W2000036071 cites W2073452121 @default.
- W2000036071 cites W2073575984 @default.
- W2000036071 cites W2074433596 @default.
- W2000036071 cites W2076075378 @default.
- W2000036071 cites W2077173862 @default.
- W2000036071 cites W2077478539 @default.
- W2000036071 cites W2078652183 @default.
- W2000036071 cites W2080137732 @default.
- W2000036071 cites W2083983329 @default.
- W2000036071 cites W2086107539 @default.
- W2000036071 cites W2089614570 @default.
- W2000036071 cites W2090551359 @default.
- W2000036071 cites W2094079572 @default.
- W2000036071 cites W2095485039 @default.
- W2000036071 cites W2097767970 @default.
- W2000036071 cites W2103066559 @default.
- W2000036071 cites W2107813980 @default.
- W2000036071 cites W2108222684 @default.